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Cellular Biology

Many cellular functions are controlled and/or modulated by integrins , transmembrane proteins structured as  αβ heterodimers. Interactions of integrins, as receptors, with either extracellular matrix proteins or partners in other cell membranes, represent for the cells a way to investigate the environment. This investigation is an active work resulting in various signaling events. These signaling pathwayseliciting integrins allow the cells to behave in the most appropriate manner, according to the signals received by the integrins themselves or/and by other cell surface receptors, by crosstalking. Therefore, the study of integrin signaling pathways and their crosstalking mechanisms with other signaling pathways proves to be helpful in understanding dynamics of cell morphology, cell movement, cell proliferation and differentiation, programmed cell death, and other cellular events useful for the knowledge of cellular physiology and pathology. Our lab approaches several directions to study integrin function in cell physiology and pathology:

1. Role of integrins in the control and modulation of apoptosis;

2. Effects of integrin-matrix protein interactions on keratinocyte proliferation;

3. Function of integrins in telocyte morphology dynamics;

4. Functions of integrins in the control and modulation of cell motility;

5. Study of cell populations in tissue regeneration.

 

 

People
Valeriu Bogdan CIŞMAŞIU, PhD
Head of the Lab

Sevinci POP, PhD
Research Associate

Gisela GAINA

Cristina Mariana NICULITE, Biochemist, PhD Student
Research Assistant

Teodor Marin REGALIA
Research Technician

 

 

 

 

 

 

 

 

       

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