{"id":12231,"date":"2025-06-25T12:39:43","date_gmt":"2025-06-25T12:39:43","guid":{"rendered":"https:\/\/www.ivb.ro\/?page_id=12231"},"modified":"2025-06-25T12:43:55","modified_gmt":"2025-06-25T12:43:55","slug":"pn-iii-p1-1-1-pd-2016-2093","status":"publish","type":"page","link":"https:\/\/www.ivb.ro\/en\/pn-iii-p1-1-1-pd-2016-2093","title":{"rendered":"PN-III-P1-1.1-PD-2016-2093"},"content":{"rendered":"
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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPN-III-P1-1.1-PD-2016-2093 \t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h4>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tNOVEL APPROACH FOR GLIOBLASTOMA THERAPY BY SIMULTANEOUS TARGETING OF NOTCH CANCER STEM CELL SIGNALING AND ANGIOGENESIS\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t

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Project ID:\u00a0PN-III-P1-1.1-PD-2016-2093<\/strong>\u00a0<\/span><\/p>

Contract number: 121 \u2044 2018<\/strong>\u00a0<\/span><\/p>

Acronim: GLIOCASTENO<\/strong><\/span><\/p>

Funding source:\u00a0State Bugdet through Romanian National Authority for Scientific Research and Innovation CNCS- The national center for<\/strong><\/span><\/p>

Funding amount:\u00a0\u00a0250.000 lei<\/strong>\u00a0<\/span><\/p>

Period:\u00a024 months<\/strong><\/span><\/p>

Project start: 01\/05\/2018<\/strong><\/span><\/p>

Project end: 30\/04\/2020<\/strong>\u00a0<\/span><\/p>

Phone: Victor Babes National Institute of Pathology<\/strong><\/span><\/p>

Project title:<\/strong>\u00a0Novel approach for glioblastoma therapy by simultaneous targeting of Notch cancer stem cell signaling and angiogenesis<\/strong><\/span><\/p>

\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u00a0<\/span><\/p>

Abstract<\/strong><\/span><\/p>

Glioblastoma multiforme (GBM) represent some of the most lethal forms of cancer, with a survival rate of 12-18 months from diagnosis and a 5 year survival rate which does not exceed 3%. Despite advances in understanding the molecular biology of glioblastoma multiforme, WHO grade IV, these aggressive tumors are still incurable. These statistics emphasize the need to develop new effective therapeutic strategies against this disease.\u00a0<\/span>
The presence of cancer stem cells in brain tumors has been suggested in the recent years, extrapolating from other types of malignancies. The Notch signaling is a important pathway for survival of cancer stem cells. Increased Notch signaling promotes tumor development, while blockage of Notch pathway suppresses proliferation and\/or survival. When considering the cross-talk between Notch signaling and the RAS\/MEK\/ERK and PI-3K\/Akt pathways downstream of EGFR and their roles in experimental gliomas, it is tempting to speculate that simultaneous inhibition of several of these pathways could lead to improved treatment of glioma patients.<\/span><\/span><\/span><\/p>

In light of recent molecular treatment resistance or inefficacy, the concomitant inhibition of Notch pathway and angiogenesis proposed in the present project could offer a promising strategy to surpass the cross talk between various pathways and to emerge as alternative therapies.\u00a0<\/span>
The main objective of the present project is Evaluation of synergic effects of multiple signaling pathway inhibition (cancer stem cell signaling – Notch, angiogenesis, PI3K signaling) as potential novel therapeutical approaches for glioblastoma treatment.\u00a0<\/span><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Project Objectives:<\/strong><\/span><\/p>

The main objective of the present project is Evaluation of synergic effects of multiple signaling\u00a0<\/span>
pathway inhibition (cancer stem cell signaling – Notch, angiogenesis, PI3K signaling) as potential\u00a0<\/span>
novel therapeutical approaches for glioblastoma treatment.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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The specific objectives<\/strong> are:\u00a0<\/span>
\u00b7 Generation and characterization of primary patient-derived glioblastoma cell cultures;\u00a0<\/span>
\u00b7 Modulation of glioblastoma cell behavior trough individual and combinatorial inhibition of\u00a0<\/span>
Notch and PI3K\/ angiogenesis;\u00a0<\/span>
\u00b7 Evaluation of synergic combinatorial effects of Notch\/ PI3K \/angiogenic inhibitors as potential\u00a0novel therapeutical approaches for glioblastoma treatment.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Team:<\/strong>\u00a0<\/strong><\/span><\/p>

Project Director: Maria Linda POPA, MD, PhD, Assistant Professor<\/strong><\/span><\/p>

Mentor: Cristiana TANASE, Prof. Habil. Dr. CS I<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

PN-III-P1-1.1-PD-2016-2093 NOVEL APPROACH FOR GLIOBLASTOMA THERAPY BY SIMULTANEOUS TARGETING OF NOTCH CANCER STEM CELL SIGNALING AND ANGIOGENESIS Project ID:\u00a0PN-III-P1-1.1-PD-2016-2093\u00a0 Contract number: 121 \u2044 2018\u00a0 Acronim: GLIOCASTENO Funding source:\u00a0State Bugdet through Romanian National Authority for Scientific Research and Innovation CNCS- UEFISCDI Funding amount:\u00a0\u00a0250.000 lei\u00a0 Period:\u00a024 months Project start: 01\/05\/2018 Project end: 30\/04\/2020\u00a0 Contractor: Victor Babes National… <\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-12231","page","type-page","status-publish","hentry"],"yoast_head":"\nPN-III-P1-1.1-PD-2016-2093 - National Institute of Pathology Victor Babe\u015f - Bucharest<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ivb.ro\/en\/pn-iii-p1-1-1-pd-2016-2093\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PN-III-P1-1.1-PD-2016-2093 - 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