{"id":1381,"date":"2021-04-09T11:07:39","date_gmt":"2021-04-09T11:07:39","guid":{"rendered":"https:\/\/www.ivb.ro\/?page_id=1381"},"modified":"2025-01-28T13:42:35","modified_gmt":"2025-01-28T13:42:35","slug":"biobaza-337ped-pn-iii-p2-2-1-ped-2019-3297","status":"publish","type":"page","link":"https:\/\/www.ivb.ro\/en\/biobaza-337ped-pn-iii-p2-2-1-ped-2019-3297","title":{"rendered":"Biobaza &#8211; 337PED- PN-III-P2-2.1-PED-2019-3297"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"1381\" class=\"elementor elementor-1381\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2d89acd0 elementor-section-content-middle elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2d89acd0\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7d05a148\" data-id=\"7d05a148\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1e5b893 elementor-view-framed elementor-shape-circle elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"1e5b893\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<a href=\"https:\/\/marichiritoiu4.wixsite.com\/ped337\" class=\"elementor-icon\" tabindex=\"-1\" aria-label=\"337PED - PN-III-P2-2.1-PED-2019-3297\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-star\" viewbox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M259.3 17.8L194 150.2 47.9 171.5c-26.2 3.8-36.7 36.1-17.7 54.6l105.7 103-25 145.5c-4.5 26.3 23.2 46 46.4 33.7L288 439.6l130.7 68.7c23.2 12.2 50.9-7.4 46.4-33.7l-25-145.5 105.7-103c19-18.5 8.5-50.8-17.7-54.6L382 150.2 316.7 17.8c-11.7-23.6-45.6-23.9-57.4 0z\"><\/path><\/svg>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h4 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<a href=\"https:\/\/marichiritoiu4.wixsite.com\/ped337\" >\n\t\t\t\t\t\t\t337PED - PN-III-P2-2.1-PED-2019-3297\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/h4>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tPlatforma automatizata de screening pentru molecule mici cu potential \nanti-inflamator\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1bc096e elementor-widget elementor-widget-text-editor\" data-id=\"1bc096e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><a href=\"https:\/\/marichiritoiu4.wixsite.com\/ped337\">https:\/\/marichiritoiu4.wixsite.com\/ped337<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28a95282 elementor-widget elementor-widget-text-editor\" data-id=\"28a95282\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: left;\"><span style=\"color: #000000;\">Context stiintific: Sistemul imun este principalul pilon pentru sanatatea organismului uman. Intelegerea aprofundata a modulatorilor imuni va permite descifrarea mecanismelor sistemului imun pentru lupta impotriva unei vaietati largi de patologii umane. Inflamatia cronica este principala caracteristica a multor patologii, inclusiv a cancerului, iar momentan terapia anti-inflamatorie este concentrata pe scaderea productiei mediatorilor eicosanoidici ai inflamatiei (prostanglandine, tromboxani, prostacicline, leukotriene) prin inhibarea ciclooxigenazelor endogene (COX-1\/2). Desi sunt eficiente, studii recente au evidentiat potentiale efecte secundare ale acestor molecule. Ca urmare, identificarea si validarea unor noi molecule cu potential anti-inflamator si efecte secundare reduse reprezinta un real interes. Recent, dezvoltarea moleculelor ce tintesc caile de semnalizare implicate in producerea si eliberarea mediatorilor pro-inflamatorii, cum sunt citokinele si chemokinele, a castigat teren si promoveaza conceptul de terapii de noua generatie.<\/span><\/p><p style=\"text-align: left;\"><span style=\"color: #000000;\">Ipoteza: Identificarea unor molecule ce tintesc producerea si secretia citokinelor pro-inflamatorii de care macrofage si monocite, precum interleukina-1\u03b2 (IL-1\u03b2), va permite un tratament alternativ imbunatatit pentru inflamatia cronica asociata numeroaselor patologii.<\/span><\/p><p style=\"text-align: left;\"><span style=\"color: #000000;\">Scop: Acest proiect isi propune dezvoltarea unei platforme de screening automatizat prin generarea unei linii celulare reporter cu IL-1\u03b2 marcata endogen, utilizand tehnologia CRISPR-CAS9, pentru monitorizarea secretiei acestei citokine, cu scopul identificarii unor noi compusi cu activitate anti-inflamatorie care vor fi validati in macrofage primare si modele animale pentru septicemie.<\/span><\/p><p style=\"text-align: left;\"><span style=\"color: #000000;\">Rezultate scontate: Implementarea acestui proiect va genera o platforma de screening versatila pentru compusi anti-inflamatori si o lista de molecule validate cu proprietati anti-inflamatoare, care poate fi usor transpusa in studii preclinice.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>337PED- PN-III-P2-2.1-PED-2019-3297 Platforma automatizata de screening pentru molecule mici cu potential anti-inflamator https:\/\/marichiritoiu4.wixsite.com\/ped337 Context stiintific: Sistemul imun este principalul pilon pentru sanatatea organismului uman. Intelegerea aprofundata a modulatorilor imuni va permite descifrarea mecanismelor sistemului imun pentru lupta impotriva unei vaietati largi de patologii umane. Inflamatia cronica este principala caracteristica a multor patologii, inclusiv a cancerului,&hellip; <\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-1381","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Biobaza - 337PED- PN-III-P2-2.1-PED-2019-3297 - National Institute of Pathology Victor Babe\u015f - Bucharest<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ivb.ro\/en\/biobaza-337ped-pn-iii-p2-2-1-ped-2019-3297\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biobaza - 337PED- PN-III-P2-2.1-PED-2019-3297 - National Institute of Pathology Victor Babe\u015f - Bucharest\" \/>\n<meta property=\"og:description\" content=\"337PED- PN-III-P2-2.1-PED-2019-3297 Platforma automatizata de screening pentru molecule mici cu potential anti-inflamator https:\/\/marichiritoiu4.wixsite.com\/ped337 Context stiintific: Sistemul imun este principalul pilon pentru sanatatea organismului uman. Intelegerea aprofundata a modulatorilor imuni va permite descifrarea mecanismelor sistemului imun pentru lupta impotriva unei vaietati largi de patologii umane. Inflamatia cronica este principala caracteristica a multor patologii, inclusiv a cancerului,&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ivb.ro\/en\/biobaza-337ped-pn-iii-p2-2-1-ped-2019-3297\/\" \/>\n<meta property=\"og:site_name\" content=\"National Institute of Pathology Victor Babe\u015f - Bucharest\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/incdvb.ro\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-28T13:42:35+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.ivb.ro\/biobaza-337ped-pn-iii-p2-2-1-ped-2019-3297\",\"url\":\"https:\/\/www.ivb.ro\/biobaza-337ped-pn-iii-p2-2-1-ped-2019-3297\",\"name\":\"Biobaza - 337PED- PN-III-P2-2.1-PED-2019-3297 - National Institute of Pathology Victor Babe\u015f - Bucharest\",\"isPartOf\":{\"@id\":\"https:\/\/www.ivb.ro\/#website\"},\"datePublished\":\"2021-04-09T11:07:39+00:00\",\"dateModified\":\"2025-01-28T13:42:35+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.ivb.ro\/biobaza-337ped-pn-iii-p2-2-1-ped-2019-3297#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.ivb.ro\/biobaza-337ped-pn-iii-p2-2-1-ped-2019-3297\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.ivb.ro\/biobaza-337ped-pn-iii-p2-2-1-ped-2019-3297#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.ivb.ro\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Biobaza &#8211; 337PED- PN-III-P2-2.1-PED-2019-3297\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.ivb.ro\/#website\",\"url\":\"https:\/\/www.ivb.ro\/\",\"name\":\"National Institute of Pathology Victor Babe\u015f - Bucharest\",\"description\":\"National Institute of Pathology Victor Babe\u015f - Bucharest\",\"publisher\":{\"@id\":\"https:\/\/www.ivb.ro\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.ivb.ro\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.ivb.ro\/#organization\",\"name\":\"National Institute of Pathology Victor Babe\u015f - Bucharest\",\"url\":\"https:\/\/www.ivb.ro\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/www.ivb.ro\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2021\/04\/top-logo.png\",\"contentUrl\":\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2021\/04\/top-logo.png\",\"width\":340,\"height\":190,\"caption\":\"National Institute of Pathology Victor Babe\u015f - Bucharest\"},\"image\":{\"@id\":\"https:\/\/www.ivb.ro\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/incdvb.ro\",\"https:\/\/www.instagram.com\/institutul.victorbabes\/\",\"https:\/\/ro.linkedin.com\/company\/victor-babes-national-institute-of-pathology\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Biobaza - 337PED- PN-III-P2-2.1-PED-2019-3297 - National Institute of Pathology Victor Babe\u015f - Bucharest","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ivb.ro\/en\/biobaza-337ped-pn-iii-p2-2-1-ped-2019-3297\/","og_locale":"en_GB","og_type":"article","og_title":"Biobaza - 337PED- PN-III-P2-2.1-PED-2019-3297 - National Institute of Pathology Victor Babe\u015f - Bucharest","og_description":"337PED- PN-III-P2-2.1-PED-2019-3297 Platforma automatizata de screening pentru molecule mici cu potential anti-inflamator https:\/\/marichiritoiu4.wixsite.com\/ped337 Context stiintific: Sistemul imun este principalul pilon pentru sanatatea organismului uman. 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