{"id":1555,"date":"2021-04-09T14:22:32","date_gmt":"2021-04-09T14:22:32","guid":{"rendered":"https:\/\/www.ivb.ro\/?page_id=1555"},"modified":"2021-04-09T14:30:26","modified_gmt":"2021-04-09T14:30:26","slug":"radiobiology-project-13-eli","status":"publish","type":"page","link":"https:\/\/www.ivb.ro\/en\/radiobiology-project-13-eli","title":{"rendered":"Radiobiology – Project 13 ELI"},"content":{"rendered":"
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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tProject 13-ELI\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h4>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tDevelopment of the national technological platform \nfor investigating the interaction of complex biological systems \nwith space radiations in the context of ELI-NP \n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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PROGRAM<\/strong><\/span><\/p>

PNCDI 3, Program 5 \u2013 Research in strategic domains, Subprogram 5.1 The research, development and innovation program for technologies in the field of ultra-power lasers \u2013 ELI-RO. Project type: R&D<\/span><\/p>

Place of the project in the framework\/context of the ELI-NP White Book <\/strong><\/span><\/p>

5.6.15 Materials research in high intensity radiation fields<\/span><\/p>

TDR4 topic 2.6. Biological systems under irradiation<\/span><\/p>

Project duration<\/strong><\/span><\/p>

01.09.2016 \u2013 31.08.2019<\/strong><\/span><\/p>

Consortium<\/strong><\/span><\/p>

Coordinator <\/strong><\/span><\/p>

\u201d<\/strong>Victor Babe\u0219\u201d National Institute of Pathology, Bucharest, ROMANIA (IVB)<\/span><\/p>

Project director: Prof. Mihail Eugen HINESCU<\/span><\/p>

Partner 1 <\/strong><\/span><\/p>

\u201cHoria Hulubei\u201d National Institute for R&D in Physics and Nuclear Engineering, M\u0103gurele, ROMANIA (IFIN-HH)<\/span><\/p>

Project responsible: Dr. Cristian POSTOLACHE<\/span><\/p>

Partner 2<\/strong><\/span><\/p>

University of Bucharest, Faculty of Biology, Bucharest, ROMANIA (UB)<\/span><\/p>

Project responsible: Assoc. Prof. Marina Tamara NECHIFOR<\/span><\/p>

Budget<\/strong><\/span><\/p>

1,070,700.00 Lei<\/strong><\/span><\/p>

Useful links<\/strong><\/span><\/p>

ELI-RO IFA http:\/\/www.ifa-mg.ro\/eli\/<\/a><\/span><\/p>

ELI \u2013NP http:\/\/www.eli-np.ro\/<\/a><\/span><\/p>

\u201cVictor Babe\u0219\u201d National Institute of Pathology http:\/\/www.ivb.ro\/v2\/index.php\/en<\/a><\/span><\/p>

\u201cHoria Hulubei\u201d National Institute for R&D in Physics and Nuclear Engineering https:\/\/www.nipne.ro\/<\/a><\/span><\/p>

University of Bucharest, Faculty of Biology http:\/\/www.unibuc.ro\/e\/facultati\/biologie\/index.php<\/a><\/span><\/p>

Project Summary<\/strong><\/span><\/p>

ELI-NP is a unique facility to generate multi-component, multi-energetic, space-like radiation in ground-based laboratory conditions, by interaction of two pulsed laser beams (1 PW, 25 fs) with two solid or gaseous targets in a large interaction chamber. Advanced studies on the interaction of complex biological system with multi-component ionizing radiation mimicking space radiation will foster knowledge and technology and help to develop an improved, evidence-based radioprotection system for deep space missions with human crew and possibly for the establishment of permanent human habitats on Mars.<\/span><\/p>

The project has as main objective to setup the technologic platform for the investigation of the interaction of multi-component ionizing radiation with complex biological systems in the context of ELI-NP, and to demonstrate its functionality using proteins and cells exposed to mono-component ionizing radiation produced in existing national facilities. The project is organized in 5 work packages (WP), as follows: WP1 \u2013 Design and optimization of the irradiation cassette for biolgical systems, WP2 \u2013 Geant4 Dose Estimations, WP3 \u2013 Dosimetric methods and measurements; WP4 \u2013 Irradiation of biologic samples with mono- and multi-component ionizing radiation, WP5 \u2013 Demonstrative biologic study.<\/span><\/p>

The project is in line with the domain 5.6.15 Materials research in high intensity radiation fields of the ELI-NP White Book. It is proposed by a Romanian multidisciplinary consortium made of two national research institutes, \u201cVictor Babes\u201d National Institute of Pathology (coordinator) and \u201cHoria Hulubei\u201d National Institute for R&D in Physics and Nuclear Engineering, in collaboration with the University of Bucharest, Faculty of Biology.<\/span><\/p>

The main project outcomes are the following: a customized irradiation cassette providing adequate experimental conditions for biologic samples (cell monolayers, cell and organoid suspensions), a standardized set of simulations for dose estimation in cell culture settings, irradiation settings and modelling of conditions for multi-component radiation, relevant for the exposure of astronauts in deep space missions, molecular pathways related to oxidative stress, antioxidant response and redox signaling in immune cells exposed to proton, electron and\/or HZE particle beams, a study-dedicated biobank to be used in the current study and in future investigations, publications and communication of results for promoting the project and ELI-NP, training of the next generation of scientists for ELI-NP.<\/span><\/p>

We emphasize that, by taking advantage of the new \u201comics\u201d technologies, the project will initiate a study for identifying critical molecular switches related to redox signaling for further developing targeted therapies to counteract the deleterious action of space radiation\u00a0 on the human organism.<\/span><\/p>

The success of the project is sustained by the expertise of participating scientists and by their commitment to apply fundamental science for developing space-related and biomedical applications at ELI-NP.
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Objectives <\/strong><\/span><\/p>

Main objective<\/em><\/strong>: <\/strong>setup of the biomedical platform for the investigation of the interaction of multi-component radiation with complex biological systems in the context of ELI-NP, and demonstration of its functionality by investigations on proteins and cells.<\/span><\/p>

Specific technologic and scientific objectives<\/em><\/strong><\/span><\/p>