{"id":6016,"date":"2023-06-13T08:37:13","date_gmt":"2023-06-13T08:37:13","guid":{"rendered":"https:\/\/www.ivb.ro\/?page_id=6016"},"modified":"2025-07-17T08:57:58","modified_gmt":"2025-07-17T08:57:58","slug":"pn-23-16-01-03","status":"publish","type":"page","link":"https:\/\/www.ivb.ro\/en\/pn-23-16-01-03","title":{"rendered":"PN 23.16.01.03"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"6016\" class=\"elementor elementor-6016\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3d964cd4 elementor-section-content-middle elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3d964cd4\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-20c25dac\" data-id=\"20c25dac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5adbb934 elementor-view-framed elementor-shape-circle elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"5adbb934\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-star\" viewbox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M259.3 17.8L194 150.2 47.9 171.5c-26.2 3.8-36.7 36.1-17.7 54.6l105.7 103-25 145.5c-4.5 26.3 23.2 46 46.4 33.7L288 439.6l130.7 68.7c23.2 12.2 50.9-7.4 46.4-33.7l-25-145.5 105.7-103c19-18.5 8.5-50.8-17.7-54.6L382 150.2 316.7 17.8c-11.7-23.6-45.6-23.9-57.4 0z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h4 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tPN 23.16.01.03\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h4>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tTHE FUNCTIONAL TRIAD IN EXPERIMENTAL MURINE PSORIASIS: IMMUNE SYSTEM - SKIN \u2013 GUT\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-d07e805 e-flex e-con-boxed e-con e-parent\" data-id=\"d07e805\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0cf90c0 elementor-widget elementor-widget-text-editor\" data-id=\"0cf90c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000; font-size: 18px;\"><span style=\"color: #339966;\"><strong>Duration:<\/strong><\/span> 2023 \u2013 2026<\/span><\/p><p><span style=\"color: #000000; font-size: 18px;\"><span style=\"color: #339966;\"><strong>Project responsible<\/strong><\/span> CSI Dr Carolina Constantin, Immunology Laboratory<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-444694e elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"444694e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-820dc75\" data-id=\"820dc75\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c24153b elementor-widget elementor-widget-image\" data-id=\"c24153b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2024\/11\/PN-2023_Triada-functionala.pdf\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"790\" height=\"444\" src=\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2024\/11\/PN-2023_Triada-functionala-1024x576.webp\" class=\"attachment-large size-large wp-image-11153\" alt=\"\" srcset=\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2024\/11\/PN-2023_Triada-functionala-1024x576.webp 1024w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2024\/11\/PN-2023_Triada-functionala-500x281.webp 500w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2024\/11\/PN-2023_Triada-functionala-300x169.webp 300w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2024\/11\/PN-2023_Triada-functionala-768x432.webp 768w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2024\/11\/PN-2023_Triada-functionala-1536x864.webp 1536w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2024\/11\/PN-2023_Triada-functionala-18x10.webp 18w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2024\/11\/PN-2023_Triada-functionala.webp 1920w\" sizes=\"(max-width: 790px) 100vw, 790px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-417a768 e-flex e-con-boxed e-con e-parent\" data-id=\"417a768\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1338be1 elementor-widget elementor-widget-text-editor\" data-id=\"1338be1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #339966;\"><strong>Project objective<\/strong><\/span><\/p><p><span style=\"color: #000000;\">The main objective of the project is represented by the characterization of the functional mechanisms and the inter-systemic communication gut - skin - immune system in autoimmune diseases (experimental murine psoriasis) with the translation of the therapy validated in this preclinical study into human cases. Thus, the aim of the project is to identify pathogenic changes at the level of the functional triad gut - skin - immune system in experimental murine psoriasis, before and after adjuvant therapies. Thereby, the gut-skin-immune system triad defines a new concept with potential applicability in the elucidation of the molecular mechanisms involved in the pathogenesis of psoriasis and with impact in (personalized) therapeutic modulation.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-161ff07 e-flex e-con-boxed e-con e-parent\" data-id=\"161ff07\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7744694 elementor-widget elementor-widget-text-editor\" data-id=\"7744694\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #339966;\"><strong>Estimated results for achieving project objectives<\/strong><\/span><\/p><p><span style=\"color: #000000;\"><em>To achieve the general objective of the project, the following will be considered:<\/em><\/span><\/p><ul><li><span style=\"color: #000000;\">Evaluation of cellular immune status in acute and chronic murine experimental psoriasis (Ps).<\/span><\/li><li><span style=\"color: #000000;\">Proteomic investigation of the inflammatory syndrome in experimental Ps (acute and chronic)<\/span><\/li><li><span style=\"color: #000000;\">Immunological and proteomic modulation of the inflammatory syndrome in experimental Ps using unconventional therapies - treatment with the specific IgY protein component<\/span><\/li><li><span style=\"color: #000000;\">Immunological and proteomic modulation of the inflammatory syndrome in experimental Ps using unconventional therapies - hypocaloric diet.<\/span><\/li><li><span style=\"color: #000000;\">Evaluation and characterization of the dynamics of the murine microbiome (skin\/gut) in the development of experimental Ps.<\/span><\/li><li><span style=\"color: #000000;\">Modulation of the microbiome (skin\/gut) in murine Ps using unconventional therapies.<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em><span style=\"color: #339966;\">This research project aims to achieve the following targets at the end of the implementation period:<\/span> <\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\">Characterization of the inflammatory syndrome through a complex clinical \/ histopathological \/ immunological \/ proteomic approach of the experimental model of acute and chronic \/ transgenic Ps, before and after adjuvant therapies<\/span><\/li><li><span style=\"color: #000000;\">Characterization of the functional triad immune system - skin - intestine in experimental Ps before and after adjuvant therapies, with impact in diagnosis and therapy.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0b30a4f e-flex e-con-boxed e-con e-parent\" data-id=\"0b30a4f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-672d265 elementor-widget elementor-widget-text-editor\" data-id=\"672d265\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #339966;\"><strong>Phase I (2023)<\/strong><\/span><\/p><p><span style=\"color: #000000;\"><strong>Title:<\/strong> Evaluation of cellular and humoral immune status in <span style=\"color: #339966;\">acute experimental murine Ps<\/span><\/span><\/p><p class=\"translation-block\"><span style=\"color: #000000\"><strong>Phase objective:<\/strong> To achieve this objective, the experimental murine model of acute Ps induced by the application of Imiquimod (IMQ) cream was designed, and subsequently characterized from a clinical, histopathological and immunological point of view. For this experimental model, the main immune cell populations and subpopulations from the peripheral blood and spleen were investigated by flow cytometry in order to evaluate the cellular immune status. To evaluate the humoral immune status in acute murine experimental Ps, a wide panel of inflammatory cytokines possibly involved in the pathogenesis of Ps was tested. Also, the experimental murine model of acute Ps was characterized from a proteomic point of view, by quantifying circulating cytokines\/chemokines.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-26006ef e-flex e-con-boxed e-con e-parent\" data-id=\"26006ef\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a020862 elementor-widget elementor-widget-image\" data-id=\"a020862\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"554\" height=\"229\" src=\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_1.1.png\" class=\"attachment-full size-full wp-image-12495\" alt=\"\" srcset=\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_1.1.png 560w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_1.1-500x209.png 500w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_1.1-300x125.png 300w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_1.1-18x8.png 18w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2df36c7 e-flex e-con-boxed e-con e-parent\" data-id=\"2df36c7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ff62d71 elementor-widget elementor-widget-text-editor\" data-id=\"ff62d71\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #000000;\">Experimental design for characterizing cellular and humoral immune status in Ps<\/span><\/p><p style=\"text-align: center;\"><a href=\"https:\/\/www.mdpi.com\/2075-4426\/13\/11\/1556\">https:\/\/www.mdpi.com\/2075-4426\/13\/11\/1556<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f970356 e-flex e-con-boxed e-con e-parent\" data-id=\"f970356\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fc3563a elementor-widget elementor-widget-text-editor\" data-id=\"fc3563a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><span style=\"color: #339966;\">Phase main results<\/span> <\/strong><\/p><ol><li><span style=\"color: #000000;\">The experimental murine model of acute Ps induced by applying IMQ-based cream to the dorsal region was developed and evaluated clinically, histopathologically, immunologically and proteomic.<\/span><\/li><li class=\"translation-block\"><span style=\"color: #000000\">The progression of the disease and the severity of the induced inflammation were assessed based on in vivo measurements (for erythema, induration and desquamation), PASI score, splenomegaly and histopathological evaluation. The results obtained revealed that the experimental model of acute Ps developed presented specific characteristics of human Ps, being reproducible and functional. <\/span><\/li><li class=\"translation-block\"><span style=\"color: #000000\">To evaluate the cellular immune status in experimental acute Ps, lymphocyte populations and subpopulations from peripheral blood and splenocyte suspensions were identified and quantified, revealing statistically significant changes for all investigated parameters.<\/span><\/li><li><span style=\"color: #000000;\">The analysis of the parameters of the cell in the peripheral blood showed decreased statistically significantly the values of the average percentage of lymphocytes T CD4 +<sup>+<\/sup> a and B, in the case of the rats in group Ps <em>vs<\/em> the control group, and the increase was statistically significant, the values of the average percentage of the T-cell-CD8a<sup>+<\/sup> - and NK-cells. For the ratio of T-CD4<sup>+<\/sup>T-CD8a<sup>+<\/sup> they have been in decline, statistically significant values of the rats in group Ps than in the control group, as a result of the distribution of the subseturilor lymphocytes of the T in the peripheral blood.<\/span><\/li><li><span style=\"color: #000000;\">The distribution of cellular parameters in the spleen revealed a similar variation trend, except in the case of NK cells where a decrease in values was recorded in mice with Ps, and the differences obtained between the two experimental groups were statistically significant.<\/span><\/li><li><span style=\"color: #000000;\">To evaluate <em>the humoral status in acute murine experimental Ps<\/em> a broad panel of inflammatory cytokines possibly involved in the pathogenesis of Ps was tested to evaluate the changes in serum levels in IMQ-induced experimental Ps; statistically significant changes in circulating levels were obtained for IL-1\u03b1, IL-1\u03b2, IL-5, IL-6, IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17, IFN-\u03b3, TNF-\u03b1, IP-10\/CXCL10, MCP-1\/CCL2, MIP-1\u03b1\/CCL3, MIP-1\u03b2\/CCL4, MIG\/CXCL9 and KC \/CXCL1.<\/span><\/li><li><span style=\"color: #000000;\">For pro-inflammatory cytokines (e.g. TNF-\u03b1, IFN-\u03b3, IL-1\u03b2, IL-15, IL-17) and a series of chemokines (e.g. MCP-1\/CCL2, MIP-1\u03b1\/CCL3, MIP-1\u03b2\/CCL4, KC\/CXCL1, IP-10\/CXCL10, MIG\/CXCL9) significantly increased serum levels were obtained in Ps mice, compared to normals. A serum profile of inflammatory cytokines and chemokines involved in <span style=\"color: #339966;\"><strong><em>acute experimental murine Ps<\/em><\/strong><\/span> induced by IMQ was established.<\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3657145 e-flex e-con-boxed e-con e-parent\" data-id=\"3657145\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a5aea9b elementor-widget elementor-widget-text-editor\" data-id=\"a5aea9b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #339966;\"><strong>Project dissemination (2023)<\/strong><\/span><\/p><p><span style=\"color: #000000;\"><strong><em>Communications at international and national conferences, with support from the project<\/em><\/strong><\/span><\/p><p><span style=\"color: #000000;\"><strong><em>EADV Symposium, 18-20 May 2023, Seville<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\"><em>NK cells pattern in psoriasiform dermatitis animal model. Constantin C, Surcel M, Munteanu AN, Isvoranu G, Neagu M.<\/em><strong>.<\/strong> Constantin C, Surcel I&#039;m personally a YEAR, Isvoranu, G, n. m. M.<\/span><\/li><li class=\"translation-block\"><span style=\"color: #000000\"><em>Circulating subsets of lymphocytes and dendritic cells in cutaneous melanoma<\/em>. Surcel M, Munteanu AN, Constantin C, Isvoranu G, Neagu M <\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>PDI 2023, 24-28 April, Iasi, Romania<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\"><em>P! NK cell phenotypic changes in the tumor setting \u2013 the next level in melanoma immunotherapy\/<\/em> Changes in the Phenotypic characteristics Of NK Cells \u2013 a New Approach to the Immunotherapy of Melanoma. Constantin C, Isvoranu, G, Surcel I&#039;m personally a YEAR, Zurac S, Electrical.<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>Publised papers in ISI journals<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\"><em>Insights into Nutritional Strategies in Psoriasis (2023). <\/em>Constantin C, Surcel I, Personally, N. M. M., Nutrients 2023, To 15, 3528. DOI10.3390\/nu15163528<\/span><\/li><li><span style=\"color: #000000;\"><em>Immune Portrayal of a New Therapy Targeting Microbiota in an Animal Model of Psoriasis (2023). <\/em>Surcel, M, Constantin C, Munteanu, A., Costea D., Isvoranu, G, Codrici E, Popescu, I, D, T, C, Ibram To, The Members, M. J. Pers. Avg. 2023, may 13, 1556. doi.org\/10.3390\/jpm13111556<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>Papers in the social sciences and with the support of the project<\/em><\/strong><\/span><\/p><p><span style=\"color: #000000;\">The congress of the University of Medicine and Pharmacy \u201cCarol Davila\u201d, Bucharest, 26-28 October, 2023 | Perspectives for Interdisciplinary research<\/span><\/p><ul><li><span style=\"color: #000000;\"><em>Immune portrayal of psoriasis dynamics in an experimental model. <\/em>Michaela Surcel.<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>The homepage of the web project, PN23.16.01.03<\/em><\/strong><\/span><\/p><p><span style=\"color: #000000;\">It was carried out the project web page:<\/span> <a href=\"https:\/\/www.ivb.ro\/en\/pn-23-16-01-03\/\">https:\/\/www.ivb.ro\/pn-23-16-01-03<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1060bf1 e-flex e-con-boxed e-con e-parent\" data-id=\"1060bf1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c3f75ef elementor-widget elementor-widget-text-editor\" data-id=\"c3f75ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #339966;\"><strong>Phase II (2024)<\/strong><\/span><\/p><p><span style=\"color: #000000;\"><strong>Title:<\/strong> Evaluation of cellular and humoral immune status in <span style=\"color: #339966;\">chronic murine experimental Ps<\/span><\/span><\/p><p><span style=\"color: #000000;\"><strong>Phase objective:<\/strong> To achieve this objective, an experimental murine model of chronic\/systemic Ps was initiated by applying Imiquimod (IMQ) cream concomitantly with intraperitoneal IMQ injection. This model was characterized clinically, histopathologically and immunologically. The immunological characterization was based on flow cytometry quantification of the main immune cell populations and subpopulations in peripheral blood and spleen, thus evaluating the cellular immune status in chronic\/systemic murine Ps. Also, for this experimental murine model, the dosage of circulating inflammatory cytokines\/chemokines was performed<\/span><\/p><p><span style=\"color: #000000;\"><strong><span style=\"color: #339966;\">Phase main results<\/span> <\/strong><\/span><\/p><ol><li class=\"translation-block\"><span style=\"color: #000000\">The experimental murine model of chronic systemic Ps was established and evaluated clinically, histopathologically and immunologically. The progression of the disease and the severity of inflammation were assessed based on weekly in vivo measurements for erythema, induration and desquamation, PASI score, splenomegaly, hepatomegaly and histopathological evaluation. The results obtained revealed that the experimental model of chronic systemic Ps developed presented specific characteristics of human Ps, being reproducible and functional.<\/span><\/li><li class=\"translation-block\"><span style=\"color: #000000\">Analysis of cellular parameters in peripheral blood revealed a statistically significant decrease in the mean % values of B lymphocytes in Ps mice vs. the control group. A decrease in the mean % values of T-CD8a+ lymphocytes and NK cells was observed, but without statistical relevance<\/span><\/li><li><span style=\"color: #000000;\">The distribution of the parameters of the cell in the spleen showed the decrease was statistically significant values of the average percentage of B-lymphocytes and NK-cells in the group of the Ps, chronic as compared to the control group. Also, there has been a reversal in the trend of the variation observed in the peripheral blood lymphocytes of the T-CD8a<sup>+<\/sup>for which he has been an increase in the values of the average percentage in the case of the mice in the group, the Ps process, but without statistical significance.<\/span><\/li><li class=\"translation-block\"><span style=\"color: #000000\">Using protein microarray technology, a wide panel of inflammatory cytokines possibly involved in the pathogenesis of Ps was tested to evaluate changes in serum levels in experimental Ps induced by IMQ; statistically significant changes in circulating levels were obtained for both cytokines from the Th1 panel (e.g., IL-1a, IL-6, IL-15) and cytokines from the Th2 panel (e.g., IL-5, IL-10, IL-13). In addition, data on the profile of chemokines in the chronic inflammatory process of the skin (e.g., CCL11, MIP-1 gamma) focus the direction of the study also towards the subcategory of chemokines, emphasizing the need for a repositioning of their role in other pathologies - Ps than those where studies are more numerous (atopic dermatitis, allergies). Thus, the serum profile of inflammatory cytokines and chemokines in experimental chronic murine Ps-IMQ induced was established.<\/span><\/li><\/ol><p><span style=\"color: #339966;\"><strong>Project dissemination (2024)<\/strong><\/span><\/p><p><span style=\"color: #000000;\"><strong><em>Communications at international and national conferences, with support from the project<\/em><\/strong><\/span><\/p><p><span style=\"color: #000000;\"><strong><em>8th National Symposium with International Participation ARSAL, 29 March 2024, Bucharest<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\"><strong><em>The experimental model of psoriasiform dermatitis is characterized by major dysregulation of lymphocyte subpopulations<\/em><\/strong><em>, <\/em>M, Surcel, The Munteanu G, Isvoranu, YES, Costea, e. g. Dobre, C, Constantine, M. Program, WHICH 2066-2599<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>PDI 2024, 16-19 April, Iasi, Romania<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\"><strong><em>NK cells phenotype in experimental psoriasis<\/em><\/strong><em>, <\/em>Adriana Munteanu, Mihaela, Surcel, Sima Isvoranu, Carolina Constantin, Monica Neagu \u2013 poster<\/span><\/li><li><span style=\"color: #000000;\"><strong><em>Dynamics of immune parameters in experimental murine psoriasis<\/em><\/strong><em>, <\/em>Michaela Surcel, Adriana Munteanu, Sima Isvoranu, Elena Georgiana Dobre, Carolina Constantin, Monica Is A Priority.<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>The 17th Edition of the National Congress of Cytometry, 16-17 May 2024, Bucharest<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\"><strong><em>Identification of IL-8 and TIMP2 as biomarkers of tumor progression and immune infiltration in cutaneous squamous cell carcinomas (CSCs) <\/em><\/strong>Georgiana Dobre, Munteanu, the YEAR of The Surcel, Carolina Constantin, Monica is a Priority.<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>7th European Congress of Immunology, 1-4 Sept 2024, Dublin<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\"><em>Pro-inflammatory cytokine\/chemokines pattern in obesity induced experimental psoriasis. Carolina Constantin, Mihaela Surcel, Adriana Narcisa Munteanu, Gheorghita Isvoranu, Neagu Teodora Monica<\/em><strong>.<\/strong> Carolina Constantin, Mihaela Surcel, Adriana Cecilia Munteanu, Gheorghita, Isvoranu, Monday, The Center Of Monica.<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>International Pathology Conference of the \u201eVictor Babe\u0219\u201d Institute, 7-8 November, Bucharest<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\"><strong><em>Alteration of immune parameters in experimental psoriasis, <\/em><\/strong>M, Surcel, The Munteanu G, Isvoranu, G, No Person Is Codrici, Mr. Smith, Of Ibram, C, Constantine, M. Program<\/span><\/li><li><span style=\"color: #000000;\"><strong><em>Immunological investigation of functional immunodeficiencies with respiratory manifestations, <\/em><\/strong>He Didn&#039;t Munteanu M, Surcel, C, Constantine, M. Program<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>\u00a0<\/em><\/strong><\/span><\/p><p><span style=\"color: #000000;\"><strong><em>\u00a0<\/em><\/strong><\/span><\/p><p><span style=\"color: #000000;\"><strong><em>Publised papers in ISI journals<\/em><\/strong><\/span><\/p><ol><li><span style=\"color: #000000;\"><em>Assessment of the RAS-RAF-MAPK Pathway Mutation Status in Healthy Skin, Benign Nevi and Cutaneous Melanomas: a Pilot Study Using Droplet Digital PCR , <\/em>Person E. G., Stop L. A., Popp, C., Zurac, S., Frank, M., 2024. International Journal of Molecular Sciences, 25(4):2308, DOI:10.3390\/ijms25042308<\/span><\/li><li><span style=\"color: #000000;\"><em>Intercommunicating avenues cytokines networks in psoriasis<\/em>. Michaela Surcel, Adriana Munteanu, Carolina Constantin, Monica Neagu, 2024, the Journal of Cell Identity, 3(1), 1-20, DOI: 10.47570\/play the game.2024.006<\/span><\/li><li><span style=\"color: #000000;\"><em>CAR-T Cells -Main Steps for Obtaining a Proper &#8222;Live Drug&#8221; Adoptive Therapy<\/em>Monica Neagu, Carolina Constantin, 2024, The South East European Journal of Immunology, 7(1):13-20, DOI:10.3889\/seejim.2024.6063<\/span><\/li><li><span style=\"color: #000000;\"><em>Investigating the EGFR, BRAF and RAS mutations in oral and cutaneous squamous cell neoplasms: a preliminary report on the Romanian patients, <\/em>Person, E. G. Caruntu, A., Munteanu, N. A., Surcel, M., Constantin, C., Caruntu C, Scheau, C., Frank, M., 2024. Romanian Journal of Military Medicine. DOI: 10.55453\/rjmm.2024.127.5.2<\/span><\/li><\/ol><p><span style=\"color: #000000;\"><strong><em>Other information supporting the project<\/em><\/strong><\/span><\/p><p><span style=\"color: #000000;\">Immunology Lab personnel membership to the COST Network: <em>The COST of the Action<\/em> CA21108\u00a0<em>European Network for Skin Engineering and Modeling <\/em>NETSKINMODELS - promoter of future collaborations on the project topic<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-37ba439 e-flex e-con-boxed e-con e-parent\" data-id=\"37ba439\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5c3896f elementor-widget elementor-widget-image\" data-id=\"5c3896f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"569\" height=\"329\" src=\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_2.3-scaled.png\" class=\"attachment-full size-full wp-image-12494\" alt=\"\" srcset=\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_2.3-scaled.png 2560w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_2.3-scaled-500x284.png 500w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_2.3-300x170.png 300w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_2.3-1024x582.png 1024w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_2.3-768x436.png 768w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_2.3-1536x873.png 1536w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_2.3-2048x1164.png 2048w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_2.3-18x10.png 18w\" sizes=\"(max-width: 569px) 100vw, 569px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4acf7e4 e-flex e-con-boxed e-con e-parent\" data-id=\"4acf7e4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4cc265a elementor-widget elementor-widget-text-editor\" data-id=\"4cc265a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000;\"><span style=\"color: #339966;\"><strong><em>Ps pathogenesis:<\/em><\/strong><\/span><em> interrelationship of innate and adaptive immunity via cellular and humoral factors<\/em><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e94ad4 e-flex e-con-boxed e-con e-parent\" data-id=\"5e94ad4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-768ace2 elementor-widget elementor-widget-text-editor\" data-id=\"768ace2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #339966;\"><strong>Phase III 2025 <em>(ongoing)<\/em><\/strong><\/span><\/p><p class=\"translation-block\"><span style=\"color: #000000\"><strong>Title: Immunological and proteomic modulation of the inflammatory syndrome in <span style=\"color: #339966\">  experimental psoriasis<\/span>  using  <span style=\"color: #339966\">unconventional therapies<\/span><\/span><\/p><p class=\"translation-block\"><span style=\"color: #000000\"><strong>Phase objective:<\/strong>  Evaluation of cellular and humoral immune status in experimental murine Ps treated with IgY isolated from hyperimmune egg. The experimental murine model of Ps induced by applying IMQ-based cream was established, and this model was subjected to an unconventional therapy - the IgY protein component isolated from the yolk of hyperimmune egg, from chickens immunized with antibiotic-resistant pathogenic bacteria. The experimental model was characterized from a clinical, histopathological and immuno-proteomic point of view. The main immune cell populations and subpopulations (from peripheral blood and spleen) were investigated and circulating inflammatory cytokines\/chemokines were quantified, in order to evaluate the cellular and humoral immune status.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-549a036 e-flex e-con-boxed e-con e-parent\" data-id=\"549a036\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f676624 elementor-widget elementor-widget-image\" data-id=\"f676624\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"498\" height=\"350\" src=\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_3.3.png\" class=\"attachment-full size-full wp-image-12496\" alt=\"\" srcset=\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_3.3.png 502w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_3.3-500x352.png 500w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_3.3-300x210.png 300w, https:\/\/www.ivb.ro\/wp-content\/uploads\/2025\/07\/23.16.01.03-_3.3-18x12.png 18w\" sizes=\"(max-width: 498px) 100vw, 498px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a74754b e-flex e-con-boxed e-con e-parent\" data-id=\"a74754b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6675c93 elementor-widget elementor-widget-text-editor\" data-id=\"6675c93\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #000000;\">Experimental scheme regarding the further development of the project<\/span><\/p><p style=\"text-align: center;\"><a href=\"https:\/\/www.mdpi.com\/2075-4426\/13\/11\/1556\">https:\/\/www.mdpi.com\/2075-4426\/13\/11\/1556<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-073ae48 e-flex e-con-boxed e-con e-parent\" data-id=\"073ae48\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fe45ae6 elementor-widget elementor-widget-text-editor\" data-id=\"fe45ae6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000;\"><strong><span style=\"color: #339966;\">Phase main results<\/span> <\/strong><\/span><\/p><ol><li><span style=\"color: #000000;\">The experimental murine model of Ps induced by IMQ was developed and evaluated from a clinical, histopathological and immunoproteomic point of view, before and after treatment with the IgY protein component.<\/span><\/li><li class=\"translation-block\"><span style=\"color: #000000\">To evaluate <strong> the cellular immune status in experimental<\/strong> Ps before IgY therapy, lymphocyte populations\/subpopulations were identified and quantified in peripheral blood and splenocyte suspensions, with statistically significant changes for all investigated parameters.<\/span><\/li><li class=\"translation-block\"><span style=\"color: #000000\">In peripheral blood, a statistically significant decrease in the mean % values of T-CD4+ and B lymphocytes was observed in mice with induced Ps vs. the Ctrl group, and a statistically significant increase in the mean % values of T-CD8a+ lymphocytes and NK cells.<\/span><\/li><li><span style=\"color: #000000;\">The analysis of the suspension of the splenocite found that the mice with the Ps, the indus script has been in decline, statistically significant values of % the average of the T-cell-CD4<sup>+<\/sup>A , B, and NK cells, with a significant increase in the values of the T-cell-CD8a<sup>+<\/sup>.<\/span><\/li><li class=\"translation-block\"><span style=\"color: #000000\">Splenocyte suspension analysis revealed that for mice with induced Ps, statistically significant decreases in the mean % values of T-CD4+, B and NK cells were recorded, along with significant increases in T-CD8a+ lymphocytes.<\/span><\/li><li><span style=\"color: #000000;\">Serum cytokine analysis revealed significantly increased serum levels of IL-6, IL-1\u03b2, IFN-\u03b3, TNF-\u03b1, IL-5, IL-10, IL-17, MCP-1 (CCL2), MIP-1\u03b1 (CCL3), RANTES (CCL5), PF4 (CXCL4), ICAM-1, TIMP-1, leptin and eotaxin, in mice with induced Ps compared to healthy mice.<\/span><\/li><li><span style=\"color: #000000;\">For the experimental murine model of Ps induced by IMQ thus created and characterized, the effect of treatment with the IgY protein component on the evolution of the clinical condition, as well as the dynamics of the cellular and humoral immune status, was monitored.<\/span><\/li><li class=\"translation-block\"><span style=\"color: #000000\">Following unconventional therapy - oral treatment with IgY - an improvement in the clinical evolution was observed, as well as a normalization of the investigated cellular and humoral parameters. As IgY can be prepared specifically and individually, this product could open a personalized field in the adjuvant therapy of Ps.<\/span><\/li><\/ol><p><span style=\"color: #339966;\"><strong>Project dissemination 2025 <em>(ongoing)<\/em><\/strong><\/span><\/p><p><span style=\"color: #000000;\"><strong><em>Papers published in ISI journals<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\">Antibodies Against Melanoma Antigens \u2013 Clinical and Therapeutical Markers. Neagu M, Constantin C, Dobre E G a, Zurac, THE J Dermatol Res. 2025;6(1):1-22.<\/span><\/li><li><span style=\"color: #000000;\">Psoriatic stem cells and obesity: metabolic science for therapeutics. Constantin, C., Dobre, E. G., Munteanu, N. A., Surcel, M., Caruntu C, Zurac S, Frank M, J Med Life, 2025. (<em>in the press<\/em>)<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>Communications at international and national conferences, with support from the project <\/em><\/strong><\/span><\/p><p><span style=\"color: #000000;\"><strong><em>Conference Bioinformatics Horizons \u201825, Bucharest, Romania, April 2-4, 2025<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\"><em>Assessing high-fat diet-induced gut microbiota changes in psoriasis mouse models: implications for developing novel therapeutic strategies, E.G. Dobre, P. Istvan, A.N. Munteanu, M. Surcel, G. Isvoranu, C. Constantin, M. Neagu<\/em><\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>Cancer ImmunoTherapy &amp; ImmunoMonitoring \u2013 CITIM, March 31 \u2013 April 3, 2025, Bucharest<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\"><em>Adipokines and gut microbiome shape the outcome of cutaneous melanoma: preliminary insights, C Constantin, EG Dobre, AN Munteanu, M Surcel, SA Zurac, M Neagu<\/em><\/span><\/li><li><span style=\"color: #000000;\"><em>Insights in genetic and epigenetic traits in cutaneous melanoma - new therapy targets, M Neagu, Dobre EG, Constantin C, Surcel M, Munteanu A, Zurac S.<\/em><\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>PDI 2025, 7-12 April 2025, Ia\u0219i, Romania<\/em><\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\"><em>New possible adjuvant therapies in experimental psoriasis, M Surcel, AN Munteanu, G Isvoranu, G Dobre, C Constantin, M Neagu.<\/em>.<\/span><\/li><li><span style=\"color: #000000;\"><em>Mutational profiling in skin cancers, M Neagu, C Constantin EG Dobre, M Surcel, AN Munteanu, S Zurac<\/em><\/span><\/li><li><span style=\"color: #000000;\"><em>Crosstalk between microbiome and immunity in cutaneous melanomaC Constantin EG Dobre, AN Munteanu, M Surcel, SA Zurac, M Neagu<\/em><\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong><em>Other information supporting the project: <\/em><\/strong>Immunology Lab personnel membership to the COST Network: COST Action CA21108 European Network for Skin Engineering and Modeling NETSKINMODELS - promoter of future collaborations on the project topic<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>PN 23.16.01.03 TRIADA FUNC\u021aIONAL\u0102 \u00ceN PSORIAZISUL EXPERIMENTAL MURIN: SISTEM IMUN \u2013 PIELE &#8211; INTESTIN Derulare: 2023 \u2013 2026 Director de proiect: CSI Dr Carolina Constantin, Laborator Imunologie Obiectivul proiectului Prezentul proiect de cercetare are ca obiectiv general caracterizarea mecanisticii func\u021bionale \u0219i a comunic\u0103rii inter-sistemice intestin &#8211; piele &#8211; sistem imun \u00een boli autoimune (psoriazisul experimental&hellip; <\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-6016","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PN 23.16.01.03 - National Institute of Pathology Victor Babe\u015f - Bucharest<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ivb.ro\/en\/pn-23-16-01-03\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PN 23.16.01.03 - National Institute of Pathology Victor Babe\u015f - Bucharest\" \/>\n<meta property=\"og:description\" content=\"PN 23.16.01.03 TRIADA FUNC\u021aIONAL\u0102 \u00ceN PSORIAZISUL EXPERIMENTAL MURIN: SISTEM IMUN \u2013 PIELE &#8211; 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