{"id":6080,"date":"2023-06-26T09:38:26","date_gmt":"2023-06-26T09:38:26","guid":{"rendered":"https:\/\/www.ivb.ro\/?page_id=6080"},"modified":"2025-12-10T12:40:33","modified_gmt":"2025-12-10T12:40:33","slug":"pn-23-16-02-02","status":"publish","type":"page","link":"https:\/\/www.ivb.ro\/en\/pn-23-16-02-02","title":{"rendered":"PN 23.16.02.02"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"6080\" class=\"elementor elementor-6080\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-12927c2b elementor-section-content-middle elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"12927c2b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5682670d\" data-id=\"5682670d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-205ed92f elementor-view-framed elementor-shape-circle elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"205ed92f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-star\" viewbox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M259.3 17.8L194 150.2 47.9 171.5c-26.2 3.8-36.7 36.1-17.7 54.6l105.7 103-25 145.5c-4.5 26.3 23.2 46 46.4 33.7L288 439.6l130.7 68.7c23.2 12.2 50.9-7.4 46.4-33.7l-25-145.5 105.7-103c19-18.5 8.5-50.8-17.7-54.6L382 150.2 316.7 17.8c-11.7-23.6-45.6-23.9-57.4 0z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h4 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tPN 23.16.02.02\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h4>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tApproach to the therapeutic combination based on the adoptive transfer of NK cells, and an inhibitor of TGFBRI\/II melanoma, metastatic\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aee7023 elementor-widget elementor-widget-text-editor\" data-id=\"aee7023\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000;\"><b>CSII Dr. Gheorghi\u021ba ISVORANU<\/b><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b6c4aaf elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b6c4aaf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b704828 elementor-widget elementor-widget-text-editor\" data-id=\"b704828\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.ivb.ro\/wp-content\/uploads\/2023\/06\/Prezentare_PN_Isvoranu.pdf\">Overview<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29aee08 elementor-widget elementor-widget-text-editor\" data-id=\"29aee08\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000;\">The project proposes an innovative approach to a therapeutic method that is based on the NK cells are activated by cytokines, and the administration of an inhibitor of the receptor TGF-\u03b2, which may provide an improved method for the treatment of metastatic melanoma.<\/span><\/p><p><span style=\"color: #000000;\"><strong>The purpose<\/strong> of the project is the establishment of the molecular profiling of NK cells for the monitoring of anti-tumor, and identification of new methods of immunotherapy in metastatic melanoma, in view of the current trends of the medicine and the accuracy in the advanced stages of cancer.<\/span><\/p><p><span style=\"color: #000000;\"><strong>Objectives:<\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\">The generation of NK cells are activated by cytokines<\/span><\/li><li><span style=\"color: #000000;\">Validation of in vitro activity, the increased antitumor activity of NK-cells are activated by cytokines, and treatment with an inhibitor of TGFBRI\/S<\/span><\/li><li><span style=\"color: #000000;\">The validation of the in vivo activity of the crecute range of cells and NK are activated by cytokines, and treatment with an inhibitor of TGFBRI\/II as a potential candidate for the treatment of cancer by using the models of murine melanoma<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><strong>Expected results:<\/strong><br \/>\u2013 Achieve cells and NK-cells with cytotoxic activity increased. <br \/>\u2013 The identification of potential molecular markers on NK cells for the monitoring of anti-tumour agent. <br \/>\u2013 The identification and evaluation of dosing regimens for optimal transfer is adopted for the cells and NK-cells in metastatic melanoma. <br \/>\u2013 The identification and evaluation of the optimal dose of TGFBRI\/S for the management of pre-clinical for the treatment of metastatic melanoma. <br \/>\u2013 The validation of the possible solutions to the patients &#039; metastatic melanoma, based on the transfer adopted by the cells and NK-cells, and an inhibitor of TGFBRI\/S.<\/span><\/p><blockquote><p><span style=\"color: #000000;\"><strong>Indicators<\/strong><\/span><\/p><\/blockquote><p><span style=\"color: #000000;\"><strong><em>Communications<\/em><\/strong><\/span><\/p><ol><li><span style=\"color: #000000;\">Role of the scavenger receptor CD36 in diet-induced obesity, and metastatic melanoma. Gheorghita Isvoranu, Mihaela Surcel, Adriana Narcisa Munteanu, Carolina Constantin, Marioara Chiritoiu-Butnaru, Monica Teodora Neagu. 19<sup>th<\/sup> The European Association of Dermato Oncology Congress, Rome, Italy, 2023<\/span><\/li><li><span style=\"color: #000000;\">Strain Differences in the Response to Analgesia in Mice. Isvoranu Gheorghita, Anghelache Lauren\u021biu, Coman Cristin. 1st CELAS Congress, Prague, Czech Republic, 2023<\/span><\/li><li><span style=\"color: #000000;\">The High-fat diet impairs phenotype and function of Natural Killer cells in melanoma-bearing mice. Isvoranu, Mihaela Surcel, Adriana Munteanu, Carolina Constantin, Monica Neagu. 3rd Edition of the OncoHub Conference and 1st OncoHub Preconference Workshop Event, Bucharest, Romania, 2023<\/span><\/li><li><span style=\"color: #000000;\">The High-fat diet impairs phenotype and function of Natural Killer cells.Isvoranu, Mihaela Surcel, Adriana Munteanu, Carolina Constantin, Monica Neagu. International Pathology Conference of the Victor Babe\u0219 Institute, Bucharest, Romania, 2023<\/span><\/li><li><span style=\"color: #000000;\">Animal research saves lives. Gheorghi\u021ba Isvoranu. 8th ARSAL National Symposium, Bucharest, Romania, 2024<\/span><\/li><li><span style=\"color: #000000;\">Effects of high fat diet on immune cells in the tumor-bearing mice. G Isvoranu, M Surcel, A Munteanu, C Constantin, M Neagu, M Chiri\u021boiu-Butnaru. 8th ARSAL National Symposium, Bucharest, Romania, 2024<\/span><\/li><li><span style=\"color: #000000;\">Immunological evaluation of fat in the diet-induced alterations in the Grasp55-\/- mice.M Chiritoiu-Butnaru, G Chiritoiu, M Surcel, G Isvoranu. 8th ARSAL National Symposium, Bucharest, Romania, 2024<\/span><\/li><li><span style=\"color: #000000;\">Inhibiting TGF-\u03b2 signaling restores the function of cytokines-activated Natural Killer cells.  G Isvoranu, AE M\u00e2ndril\u0103, M Surcel, AN Munteanu, M Chiri\u021boiu-Butnaru. The Annual International Conference of the RSBMB 2024, Bucharest, Roamania<\/span><\/li><li><span style=\"color: #000000;\">Targeting the TGF-\u03b2 signaling to reinforce the therapeutic potential of cytokines-activated Natural Killer cells as immunotherapy in cancerG Isvoranu, M Surcel, AN Munteanu, AM Enciu, E Codrici, G Chiri\u021boiu, C Munteanu, AE M\u00e2ndril\u0103, M Chiri\u021boiu-Butnaru. International Pathology Conference of the Victor Babe\u0219 Institute Bucharest, Roamania, 2024<\/span><\/li><li><span style=\"color: #000000;\">Transforming growth factor beta impacts Natural Killer cell functionality. G Isvoranu, AM Enciu, E Codrici, M Surcel, G Chiri\u021boiu, M Chiri\u021boiu-Butnaru. The annual scientific conference of the &#8222;Cantacuzino&#8221; Institute, Bucharest, Romania, 2024<\/span><\/li><li><span style=\"color: #000000;\">Transforming growth factor-beta-impacts of the Natural Killer cell phenotype and functionality. Gheorghi\u021ba Isvoranu, Mihaela Surcel, Ana-Maria Enciu, Elena Codrici, Gabriela Chiri\u021boiu, Cristian Munteanu, Marioara Chiri\u021boiu-Butnaru. 10th Symposium on Advances in Cancer Immunology and Immunotherapy, Larissa, Greece, 2024<\/span><\/li><li><p class=\"v1ydpee1cc4cdMsoNormal\"><span style=\"color: #000000;\"><i><span lang=\"RO\">Toll Like Receptor 7\/8 agonists antitumor effects on NK cells in murine melanoma model<\/span><\/i><\/span><span lang=\"RO\"><span style=\"color: #000000;\">, G. Isvoranu, M. Surcel, A. Munteanu, A.M. Enciu, M. Chiritoiu-Butnaru, G.Chiritoiu, C. Munteanu, M. Neagu. SEE J Immunol, vol 8 No CITIM (2025). DOI:<\/span>\u00a0<\/span><a href=\"https:\/\/doi.org\/10.3889\/seejim.2025.6135\" target=\"_blank\" rel=\"noopener noreferrer\"><span lang=\"RO\">https:\/\/doi.org\/10.3889\/seejim.2025.6135<\/span><\/a><\/p><\/li><li><p class=\"v1ydpee1cc4cdMsoNormal\"><span style=\"color: #000000;\"><i><span lang=\"RO\">Phenotypic and functional characteristics of NK cells from mice with lung metastases, <\/span><\/i><span lang=\"RO\">G. Isvoranu, M. Surcel, A. Munteanu, A.M. Enciu, M. Chiritoiu-Butnaru, G. Chiritoiu, C. Munteanu, M. Neagu. A<\/span><span lang=\"PT\"> XVIII-a edi\u021bie a Congresului Na\u021bional de Citometrie, Bucure\u0219ti, Rom<\/span><span lang=\"RO\">\u00e2nia.<\/span><\/span><\/p><\/li><li><span style=\"color: #000000;\">Impairment of Natural Killer-cell-mediated tumor killing by transforming growth factor \u03b2. G. Isvoranu, M. Surcel, A.N. Munteanu, A.-M. Enciu, E. Codrici, G. Chiritoiu, C. Munteanu, M. Chiritoiu-Butnaru, M. Neagu. The 19<sup>th<\/sup> International Congress of Immunology, 17-22 August 2025, Vienna, Austria.<\/span><\/li><li><p><span style=\"color: #000000;\">The impact of high-fat diet on Natural Killer cells in tumor-bearing mice. Gheorghita Isvoranu, Mihaela Surcel, Ana-Maria Enciu, Elena Codrici, Daniela Popescu, Marioara Chiritoiu-Butnaru. Annual Pathology Conference of the &#8216;Victor Babe\u0219&#8217; Institute Bucharest, 12-14 November, 2025, Bucharest, Romania.<\/span><\/p><\/li><li><p><span style=\"color: #000000;\">Natural Killer cell adoptive transfer therapy for metastatic melanoma. Gheorghita Isvoranu, Valeriu Ci\u0219ma\u0219iu, Emanuel Fertig, Mihaela Surcel, Ana-Maria Enciu, Elena Codrici, Daniela Popescu, Andrei Niculae, Marioara Chiri\u021boiu-Butnaru, Gabriela Chiri\u021boiu, Cristian Munteanu, Livia Sima, Mihaela Gherghiceanu. Annual Pathology Conference of the &#8216;Victor Babe\u0219&#8217; Institute Bucharest, 12-14 November, 2025, Bucharest, Romania.<\/span><\/p><\/li><\/ol><p><span style=\"color: #000000;\"><strong>Publications<\/strong>\u00a0<\/span><\/p><ol><li><span style=\"color: #000000; font-size: 14px;\">The Therapeutic potential of interleukin-21 in cancer. G. Isvoranu, I Chiritoiu-The Military Academy. Front Immunol, 2024, 4:15:1369743, doi:10.3389\/fimmu.2024.1369743<\/span><\/li><li><span style=\"font-size: 14px;\"><span style=\"color: #000000;\">\u00a0Behavior testing in two different knockout mouse strains are related to chronic inflammation and oxidative stress. <\/span><a href=\"https:\/\/www.webofscience.com\/wos\/medline\/general-summary?queryJson=%5B%7B%22rowBoolean%22:null,%22rowField%22:%22AU%22,%22rowText%22:%22Dobri,%20Ana%20Maria%22%7D%5D&amp;eventMode=oneClickSearch\">Dobre Ana Maria<\/a>,\u00a0<a href=\"https:\/\/www.webofscience.com\/wos\/medline\/general-summary?queryJson=%5B%7B%22rowBoolean%22:null,%22rowField%22:%22AU%22,%22rowText%22:%22Isvoranu,%20Gheorghita%22%7D%5D&amp;eventMode=oneClickSearch\">Isvoranu Gheorghita<\/a>,\u00a0<a href=\"https:\/\/www.webofscience.com\/wos\/medline\/general-summary?queryJson=%5B%7B%22rowBoolean%22:null,%22rowField%22:%22AU%22,%22rowText%22:%22Enciu,%20Ana-Maria%22%7D%5D&amp;eventMode=oneClickSearch\">Enciu Ana-Maria<\/a>,\u00a0<a href=\"https:\/\/www.webofscience.com\/wos\/medline\/general-summary?queryJson=%5B%7B%22rowBoolean%22:null,%22rowField%22:%22AU%22,%22rowText%22:%22Hinescu,%20Mihail%20Eugen%22%7D%5D&amp;eventMode=oneClickSearch\">Hinescu Mihail Eugen<\/a>.<span style=\"color: #000000;\"> Cellular and molecular biology, 69(3);113-117. TWO 10.14715\/wcc\/2023.69.3.15<\/span><\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>PN 23.16.02.02 Abordare terapeutic\u0103 combinatorie bazat\u0103 pe transferul adoptiv de celule NK \u0219i inhibitor al TGFBRI\/II \u00een melanomul metastatic CSII Dr. Gheorghi\u021ba ISVORANU Prezentare Proiectul propune o abordare inovativ\u0103 a unei metode terapeutice bazat\u0103 pe celule NK activate cu citokine \u0219i administrarea unui inhibitor al receptorului TGF-\u03b2 care ar putea oferi o metod\u0103 \u00eembun\u0103t\u0103\u021bit\u0103 pentru&hellip; <\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-6080","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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