{"id":6179,"date":"2023-07-19T10:47:32","date_gmt":"2023-07-19T10:47:32","guid":{"rendered":"https:\/\/www.ivb.ro\/?page_id=6179"},"modified":"2026-08-17T09:57:46","modified_gmt":"2026-08-17T09:57:46","slug":"pn-23-16-01-02","status":"publish","type":"page","link":"https:\/\/www.ivb.ro\/en\/pn-23-16-01-02","title":{"rendered":"PN 23.16.01.02"},"content":{"rendered":"
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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPN 23.16.01.02\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h4>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tSarcopenia-associated neurodegenerative diseases: the definition of the molecular basis of cross-linking on the axis of the brain-to-striated muscle in order to identify prognostic factors and therapeutic targets\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Contract no.: 10 N\/2023\u00a0\u00a0\u00a0<\/span><\/p>

Project was funded by the Ministry of Research, Innovation and Digitalisation<\/span><\/p>

Duration: 2023-2025<\/span><\/p>

Within the framework of the Programme, the Nucleus: molecular Mechanisms in non-communicable diseases in major cancer in the pathology of degenerative disease of the size of the gene in the immune (MEMOGEN)<\/span><\/p>

Obiectiv: Identificarea mecanismelor moleculare determinante \u00een patogenia bolilor netransmisibile, cu impact diagnostic \u0219i terapeutic<\/span><\/p>

Responsabil de proiect:<\/b> CS I Laura Ceafalan<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tActivit\u0103\u021bi \u0219i progresul proiectului<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tIndicatori \u0219i diseminarea rezultatelor<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Prezentarea proiectului<\/strong><\/span><\/p>

Bolile neurodegenerative sunt asociate, \u00een stadiile avansate, cu modific\u0103ri importante la nivelul mu\u0219chiului scheletic, care pot contribui la reducerea mobilit\u0103\u021bii \u0219i a calit\u0103\u021bii vie\u021bii pacien\u021bilor.<\/span><\/p>

Proiectul investigheaz\u0103 mecanismele moleculare implicate \u00een comunicarea dintre mu\u0219chiul scheletic \u0219i sistemul nervos central, cu accent pe boala Parkinson. O aten\u021bie deosebit\u0103 este acordat\u0103 moleculelor circulante cu rol \u00een comunicarea inter-tisular\u0103, precum miokinele \u0219i microARN-urile (miRNA), precum \u0219i mecanismelor epigenetice care pot participa la aceast\u0103 interac\u021biune.<\/span><\/p>

Pentru investigarea axei creier\u2013mu\u0219chi sunt utilizate modele experimentale in-vitro<\/em> and in vivo studies<\/em>, care permit studierea interac\u021biunilor dintre celulele neuronale \u0219i musculare \u0219i evaluarea influen\u021bei exerci\u021biului fizic asupra mecanismelor moleculare analizate.<\/span><\/p>

Scopul proiectului<\/strong><\/span><\/p>

Scopul proiectului este identificarea \u0219i caracterizarea unor biomarkeri musculari circulan\u021bi modifica\u021bi \u00een bolile neurodegenerative asociate cu afectare muscular\u0103, cu poten\u021bial rol \u00een evaluarea prognosticului bolii \u0219i \u00een identificarea unor noi \u021binte terapeutice.<\/span><\/p>

Proiectul urm\u0103re\u0219te caracterizarea comunic\u0103rii moleculare pe axa creier\u2013mu\u0219chi prin analiza integrat\u0103 a miokinelor, miRNA-urilor \u0219i a unor mecanisme epigenetice, utiliz\u00e2nd modele experimentale de boal\u0103 Parkinson.<\/span><\/p>

Goals<\/strong><\/span><\/p>

OB1. Stabilirea unui panel de biomarkeri pentru cooperarea inter-tisular\u0103 prin molecule solubile utiliz\u00e2nd modele experimentale in-vitro<\/em> bazate pe co-culturi de neuroni dopaminergici \u0219i celule musculare.<\/span><\/p>

OB2. Evaluarea efectului antrenamentului fizic moderat asupra instal\u0103rii \u0219i progresiei afect\u0103rii musculare la modelul animal de boal\u0103 Parkinson.<\/span><\/p>

OB3. Stabilirea unui panel de biomarkeri circulan\u021bi la modelul experimental in vivo studies<\/em>, pentru investigarea cooper\u0103rii inter-tisulare prin molecule solubile \u0219i identificarea unor poten\u021biali factori de prognostic pentru progresia bolii Parkinson \u0219i instalarea afect\u0103rii musculare.<\/span><\/p>

OB4. Stabilirea unui panel de biomarkeri circulan\u021bi cu poten\u021bial prognostic la pacien\u021bi cu boal\u0103 Parkinson cu diferite grade de afectare muscular\u0103.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Activit\u0103\u021bi \u0219i progresul proiectului<\/strong><\/span><\/p>

2023 \u2013 Faza 1<\/strong><\/span><\/p>

Evaluarea cooper\u0103rii inter-tisulare prin molecule solubile pe modele experimentale in-vitro<\/em><\/span><\/p>

\u00cen prima etap\u0103 a proiectului au fost dezvoltate \u0219i optimizate modelele experimentale in-vitro<\/em> necesare investig\u0103rii comunic\u0103rii dintre celulele musculare \u0219i neuronii dopaminergici.<\/span><\/p>

Activit\u0103\u021bile au inclus optimizarea condi\u021biilor de cultivare \u0219i diferen\u021biere a celulelor musculare umane \u0219i validarea procesului de diferen\u021biere prin metode morfologice \u0219i moleculare.<\/span><\/p>

A fost dezvoltat \u0219i caracterizat un sistem de co-cultur\u0103 \u00eentre celule musculare diferen\u021biate \u0219i neuroni dopaminergici, \u00een condi\u021bii experimentale care permit compararea interac\u021biunilor celulare \u00een prezen\u021ba sau absen\u021ba unor modific\u0103ri asociate fenotipului de boal\u0103 Parkinson.<\/span><\/p>

\u00cen cadrul acestor sisteme experimentale au fost analizate profilurile unor miokine implicate \u00een comunicarea intercelular\u0103, at\u00e2t la nivel celular, c\u00e2t \u0219i \u00een mediul de cultur\u0103. Analizele au fost realizate prin tehnici complementare, incluz\u00e2nd multiplexarea proteinelor \u0219i Western blot.<\/span><\/p>

\u00cen paralel, au fost investigate profilurile de expresie ale miRNA-urilor \u0219i au fost selecta\u021bi candida\u021bi pentru analizele ulterioare.<\/span><\/p>

Au fost, de asemenea, optimizate metode pentru evaluarea unor markeri epigenetici, inclusiv analiza gradului de metilare a ADN-ului genomic.<\/span><\/p>

Activit\u0103\u021bile acestei faze au permis stabilirea platformei experimentale in-vitro<\/em> necesare investig\u0103rii dialogului molecular dintre \u021besutul muscular \u0219i cel nervos.<\/span><\/p>

\u00a0<\/p>

2024 \u2013 Faza 2<\/strong><\/span><\/p>

Ob\u021binerea \u0219i caracterizarea modelului experimental in vivo studies<\/em> de boal\u0103 Parkinson<\/span><\/p>

\u00cen cea de-a doua etap\u0103, cercet\u0103rile au fost extinse de la sistemele celulare la modele experimentale in vivo studies<\/em>.<\/span><\/p>

Au fost evaluate modele animale de boal\u0103 Parkinson \u0219i au fost stabilite loturile experimentale necesare studierii modific\u0103rilor musculare \u0219i neurologice asociate bolii.<\/span><\/p>

O component\u0103 important\u0103 a fazei a fost evaluarea efectului exerci\u021biului fizic moderat. Au fost dezvoltate \u0219i testate protocoale de antrenament pe roat\u0103 pentru roz\u0103toare, \u00een vederea investig\u0103rii influen\u021bei activit\u0103\u021bii fizice asupra \u021besutului muscular \u0219i asupra parametrilor moleculari urm\u0103ri\u021bi \u00een cadrul proiectului.<\/span><\/p>

Au fost recoltate \u0219i procesate probe de mu\u0219chi scheletic, creier \u0219i s\u00e2nge, necesare analizelor histologice, moleculare \u0219i biochimice.<\/span><\/p>

\u021aesutul muscular a fost caracterizat prin metode histologice, histochimice \u0219i morfometrice, fiind urm\u0103rite organizarea \u021besutului, caracteristicile diferitelor tipuri de fibre musculare \u0219i parametri asocia\u021bi func\u021biei mitocondriale.<\/span><\/p>

\u00cen paralel, au fost optimizate metodele necesare investig\u0103rii unui panel de miokine cu rol \u00een func\u021bia \u0219i metabolismul muscular, r\u0103spunsul la exerci\u021biu \u0219i comunicarea cu sistemul nervos central.<\/span><\/p>

Aceast\u0103 etap\u0103 a permis consolidarea modelului experimental in vivo studies<\/em> \u0219i constituirea loturilor \u0219i a colec\u021biei de probe biologice necesare etapei urm\u0103toare a proiectului.<\/span><\/p>

\u00a0<\/p>

2025 \u2013 Faza 3<\/strong><\/span><\/p>

Investigarea biomarkerilor implica\u021bi \u00een comunicarea pe axa creier\u2013mu\u0219chi<\/span><\/p>

\u00cen aceast\u0103 etap\u0103, cercet\u0103rile s-au concentrat asupra caracteriz\u0103rii biomarkerilor implica\u021bi \u00een comunicarea dintre mu\u0219chiul scheletic \u0219i sistemul nervos central \u00een modelul experimental de boal\u0103 Parkinson.<\/span><\/p>

Au fost completate loturile experimentale \u0219i au fost analizate animale \u00een func\u021bie de mai mul\u021bi parametri biologici \u0219i experimentali, incluz\u00e2nd genotipul, v\u00e2rsta, sexul \u0219i efectuarea antrenamentului fizic.<\/span><\/p>

De la animalele incluse \u00een studiu au fost recoltate probe de mu\u0219chi scheletic, creier \u0219i plasm\u0103, care au permis investigarea comparativ\u0103 a acelora\u0219i mecanisme moleculare \u00een compartimente biologice diferite.<\/span><\/p>

Analiza miokinelor<\/em><\/strong><\/span><\/p>

A fost investigat un panel de miokine cu rol \u00een homeostazia muscular\u0103, metabolism, inflama\u021bie, regenerare \u0219i r\u0103spunsul la exerci\u021biu fizic.<\/span><\/p>

Expresia acestora a fost evaluat\u0103 \u00een probe tisulare de mu\u0219chi \u0219i creier \u0219i \u00een probe biologice circulante, \u00een vederea caracteriz\u0103rii rela\u021biei dintre compartimentul periferic \u0219i sistemul nervos central.<\/span><\/p>

Au fost comparate loturi cu \u0219i f\u0103r\u0103 modific\u0103ri asociate bolii Parkinson \u0219i loturi cu \u0219i f\u0103r\u0103 exerci\u021biu fizic, pentru evaluarea influen\u021bei acestor factori asupra profilurilor moleculare investigate.<\/span><\/p>

Analiza miRNA<\/em><\/strong><\/span><\/p>

\u00cen paralel cu analiza miokinelor, au fost investigate miRNA-uri selectate pe baza relevan\u021bei lor pentru mecanismele studiate \u00een cadrul proiectului.<\/span><\/p>

Au fost optimizate \u0219i aplicate metode de analiz\u0103 a miRNA-urilor \u00een probe tisulare \u0219i circulante, \u00een vederea integr\u0103rii acestor date cu profilurile de expresie ale miokinelor.<\/span><\/p>

Analiza markerilor epigenetici<\/em><\/strong><\/span><\/p>

Au fost continuate investiga\u021biile privind mecanismele epigenetice asociate modific\u0103rilor musculare \u0219i neurologice.<\/span><\/p>

Analizele au inclus evaluarea gradului de metilare a ADN-ului genomic \u0219i investigarea unor mecanisme moleculare implicate \u00een reglarea epigenetic\u0103 \u0219i r\u0103spunsul celular la stres.<\/span><\/p>

\u00a0<\/p>

2026 \u2013 Faza 4<\/strong><\/span><\/p>

Validarea clinic\u0103 a biomarkerilor implica\u021bi \u00een comunicarea pe axa mu\u0219chi\u2013creier \u00een boala Parkinson<\/span><\/p>

\u00cen etapa actuala, cercet\u0103rile vor fi extinse c\u0103tre validarea clinic\u0103 a biomarkerilor identifica\u021bi \u0219i selecta\u021bi \u00een etapele experimentale anterioare ale proiectului.<\/span><\/p>

Studiul va urm\u0103ri evaluarea unui panel \u021bintit de biomarkeri circulan\u021bi la pacien\u021bi cu boala Parkinson \u0219i la persoane control, \u00een vederea investig\u0103rii asocierii acestora cu severitatea bolii \u0219i cu afectarea func\u021biei musculare.<\/span><\/p>

Vor fi analizate comparativ grupuri de pacien\u021bi afla\u021bi \u00een diferite stadii ale bolii Parkinson. Datele moleculare vor fi corelate cu parametri clinici relevan\u021bi pentru severitatea bolii, func\u021bia motorie \u0219i func\u021bia muscular\u0103.<\/span><\/p>

O component\u0103 a studiului va urm\u0103ri integrarea profilului miokinelor circulante cu analiza unor miRNA-uri selectate, \u00een vederea evalu\u0103rii unei semn\u0103turi moleculare asociate axei mu\u0219chi\u2013creier.<\/span><\/p>

Aceast\u0103 etap\u0103 urm\u0103re\u0219te transla\u021bia rezultatelor ob\u021binute pe modelele experimentale in-vitro<\/em> and in vivo studies<\/em> c\u0103tre patologia uman\u0103 \u0219i evaluarea poten\u021bialului biomarkerilor studia\u021bi pentru stratificarea pacien\u021bilor \u0219i pentru dezvoltarea ulterioar\u0103 a unor instrumente cu valoare prognostic\u0103.<\/span><\/p>

Stadiu: <\/strong>etap\u0103 de validare clinic\u0103 \u00een curs.<\/span><\/p>

Integrarea datelor<\/strong><\/span><\/p>

Datele moleculare ob\u021binute din plasm\u0103, mu\u0219chi \u0219i creier sunt analizate comparativ pentru caracterizarea comunic\u0103rii pe axa creier\u2013mu\u0219chi \u0219i pentru identificarea unor biomarkeri candida\u021bi cu relevan\u021b\u0103 pentru progresia bolii \u0219i afectarea muscular\u0103 asociat\u0103.<\/span><\/p>

Analiza integrat\u0103 urm\u0103re\u0219te, de asemenea, evaluarea influen\u021bei exerci\u021biului fizic asupra mecanismelor moleculare studiate.<\/span><\/p>

Metode utilizate<\/strong><\/span><\/p>

Pentru realizarea obiectivelor proiectului sunt utilizate metode complementare de biologie celular\u0103 \u0219i molecular\u0103, histologie \u0219i analiz\u0103 proteic\u0103, printre care:<\/span><\/p>

  • culturi celulare \u0219i sisteme de co-cultur\u0103 neuron\u2013mu\u0219chi;<\/span><\/li>
  • imunofluorescen\u021b\u0103 \u0219i microscopie;<\/span><\/li>
  • Western blot;<\/span><\/li>
  • multiplexare Luminex xMAP;<\/span><\/li>
  • RT-PCR \u0219i qRT-PCR;<\/span><\/li>
  • ddPCR;<\/span><\/li>
  • analiza miRNA;<\/span><\/li>
  • analiza metil\u0103rii ADN;<\/span><\/li>
  • histologie \u0219i histochimie muscular\u0103;<\/span><\/li>
  • analiz\u0103 morfometric\u0103;<\/span><\/li>
  • metode de analiz\u0103 statistic\u0103 \u0219i integrare a datelor.<\/span><\/li><\/ul>

    Relevan\u021ba proiectului<\/strong><\/span><\/p>

    Studierea integrat\u0103 a mu\u0219chiului scheletic, sistemului nervos central \u0219i biomarkerilor circulan\u021bi contribuie la o mai bun\u0103 \u00een\u021belegere a mecanismelor implicate \u00een interac\u021biunea dintre afectarea muscular\u0103 \u0219i neurodegenerare.<\/span><\/p>

    Abordarea utilizat\u0103 \u00een proiect permite investigarea axei creier\u2013mu\u0219chi din perspectiva comunic\u0103rii moleculare inter-tisulare \u0219i evaluarea modului \u00een care aceasta poate fi influen\u021bat\u0103 de progresia bolii \u0219i de activitatea fizic\u0103.<\/span><\/p>

    Rezultatele ob\u021binute \u00een cadrul proiectului sunt \u00een curs de analiz\u0103, valorificare \u0219i diseminare prin publica\u021bii \u0219i manifest\u0103ri \u0219tiin\u021bifice de specialitate.<\/span><\/p>

    Rezultate estimate ale proiectului<\/strong><\/span><\/p>

    • modele experimentale proof-of-concept in vitro<\/em> and in vivo studies<\/em> pentru studierea comunic\u0103rii pe axa creier\u2013mu\u0219chi;<\/span><\/li>
    • caracterizarea unor molecule implicate \u00een comunicarea dintre \u021besutul muscular \u0219i sistemul nervos central;<\/span><\/li>
    • identificarea unor profiluri de miokine \u0219i miRNA cu poten\u021bial\u0103 relevan\u021b\u0103 pentru progresia bolilor neurodegenerative;<\/span><\/li>
    • caracterizarea unor mecanisme epigenetice asociate proceselor investigate;<\/span><\/li>
    • selectarea unor biomarkeri candida\u021bi pentru studii ulterioare de validare.<\/span><\/li><\/ul>

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      Indicatori \u0219i diseminarea rezultatelor<\/strong><\/span><\/p>

      \u00a0<\/p>

      Activit\u0103\u021bile desf\u0103\u0219urate \u00een cadrul proiectului au condus la dezvoltarea \u0219i utilizarea unor modele experimentale in-vitro<\/em> and in vivo studies<\/em>, optimizarea unor metode de analiz\u0103 molecular\u0103 \u0219i tisular\u0103 \u0219i diseminarea rezultatelor prin publica\u021bii \u0219i particip\u0103ri la manifest\u0103ri \u0219tiin\u021bifice.<\/strong><\/span><\/p>

      \u00a0<\/p>

      Indicatori de cercetare-dezvoltare<\/strong><\/span><\/p>

      Perioada<\/strong><\/span><\/p><\/td>

      Categoria<\/strong><\/span><\/p><\/td>

      Indicator \/ activitate realizat\u0103<\/strong><\/span><\/p><\/td>

      Stadiu<\/strong><\/span><\/p><\/td><\/tr>

      2023<\/strong><\/span><\/p><\/td>

      Modele experimentale in-vitro<\/em><\/strong><\/span><\/p><\/td>

      Dezvoltarea \u0219i optimizarea sistemelor experimentale pentru investigarea interac\u021biunii neuron\u2013mu\u0219chi<\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2023<\/strong><\/span><\/p><\/td>

      Culturi celulare<\/strong><\/span><\/p><\/td>

      Optimizarea diferen\u021bierii celulelor musculare \u0219i a neuronilor dopaminergici utiliza\u021bi \u00een sistemele experimentale<\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2023<\/strong><\/span><\/p><\/td>

      Co-culturi<\/strong><\/span><\/p><\/td>

      Stabilirea \u0219i caracterizarea sistemelor de co-cultur\u0103 neuron\u2013mu\u0219chi<\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2023<\/strong><\/span><\/p><\/td>

      Biomarkeri<\/strong><\/span><\/p><\/td>

      Investigarea profilurilor de miokine \u0219i miRNA \u00een sistemele experimentale in-vitro<\/em><\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2023<\/strong><\/span><\/p><\/td>

      Epigenetic\u0103<\/strong><\/span><\/p><\/td>

      Optimizarea metodelor pentru investigarea unor markeri epigenetici<\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2024<\/strong><\/span><\/p><\/td>

      Modele experimentale in vivo studies<\/em><\/strong><\/span><\/p><\/td>

      Dezvoltarea \u0219i caracterizarea modelului animal utilizat pentru studiul bolii Parkinson<\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2024<\/strong><\/span><\/p><\/td>

      Exerci\u021biu fizic<\/strong><\/span><\/p><\/td>

      Implementarea unui model experimental de antrenament fizic<\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2024<\/strong><\/span><\/p><\/td>

      Caracterizare tisular\u0103<\/strong><\/span><\/p><\/td>

      Evaluarea \u021besutului muscular prin metode histologice, histochimice \u0219i morfometrice<\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2024\u20132025<\/strong><\/span><\/p><\/td>

      Probe biologice<\/strong><\/span><\/p><\/td>

      Constituirea loturilor experimentale \u0219i a colec\u021biei de probe de plasm\u0103, mu\u0219chi \u0219i creier<\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2025<\/strong><\/span><\/p><\/td>

      Biomarkeri<\/strong><\/span><\/p><\/td>

      Investigarea comparativ\u0103 a miokinelor circulante \u0219i tisulare<\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2025<\/strong><\/span><\/p><\/td>

      miRNA<\/strong><\/span><\/p><\/td>

      Investigarea \u0219i validarea miRNA-urilor selectate \u00een probe biologice<\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2025<\/strong><\/span><\/p><\/td>

      Epigenetic\u0103<\/strong><\/span><\/p><\/td>

      Investigarea markerilor epigenetici \u00een probele biologice<\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2025<\/strong><\/span><\/p><\/td>

      Integrarea datelor<\/strong><\/span><\/p><\/td>

      Analiza comparativ\u0103 a datelor ob\u021binute din plasm\u0103, mu\u0219chi \u0219i creier \u0219i corelarea cu modelele experimentale in-vitro<\/em><\/strong><\/span><\/p><\/td>

      Realizat<\/strong><\/span><\/p><\/td><\/tr>

      2026<\/strong><\/span><\/p><\/td>

      Validare clinic\u0103<\/strong><\/span><\/p><\/td>

      Preg\u0103tirea etapei de validare clinic\u0103 a biomarkerilor selecta\u021bi la pacien\u021bi cu boala Parkinson \u0219i persoane control<\/strong><\/span><\/p><\/td>

      \u00cen preg\u0103tire<\/strong><\/span><\/p><\/td><\/tr><\/tbody><\/table>

      Detaliile rezultatelor experimentale originale \u0219i ale biomarkerilor selecta\u021bi vor fi prezentate dup\u0103 valorificarea \u0219i diseminarea acestora prin publica\u021bii \u0219tiin\u021bifice.<\/em><\/strong><\/span><\/p>

      \u00a0<\/p>

      Indicatori de diseminare<\/strong><\/span><\/p>

      An<\/strong><\/span><\/p><\/td>

      Categorie<\/strong><\/span><\/p><\/td>

      Num\u0103r<\/strong><\/span><\/p><\/td><\/tr>

      2023<\/strong><\/span><\/p><\/td>

      Publica\u021bii \/ capitole de carte<\/strong><\/span><\/p><\/td>

      3<\/strong><\/span><\/p><\/td><\/tr>

      2023<\/strong><\/span><\/p><\/td>

      Comunic\u0103ri la manifest\u0103ri \u0219tiin\u021bifice \u2013 prezent\u0103ri orale<\/strong><\/span><\/p><\/td>

      2<\/strong><\/span><\/p><\/td><\/tr>

      2024<\/strong><\/span><\/p><\/td>

      Articole \u0219tiin\u021bifice<\/strong><\/span><\/p><\/td>

      1<\/strong><\/span><\/p><\/td><\/tr>

      2026<\/strong><\/span><\/p><\/td>

      Articole \u0219tiin\u021bifice<\/strong><\/span><\/p><\/td>

      5<\/strong><\/span><\/p><\/td><\/tr>

      2026<\/strong><\/span><\/p><\/td>

      Abstracte de conferin\u021b\u0103 publicate<\/strong><\/span><\/p><\/td>

      1<\/strong><\/span><\/p><\/td><\/tr><\/tbody><\/table>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

      \n\t\t\t\t\t\t
      \n\t\t\t\t\t
      \n\t\t\t
      \n\t\t\t\t\t\t
      \n\t\t\t\t
      \n\t\t\t\t\t\t\t\t\t

      Publica\u021bii \u0219i diseminare \u0219tiin\u021bific\u0103<\/strong><\/span><\/p>

      \u00a0<\/p>

      2023<\/strong><\/span><\/p>

      Publica\u021bii \/ capitole de carte<\/strong><\/span><\/p>

      1. Ioghen O.C., Ceafalan L.C., Popescu B.O. SH-SY5Y Cell Line In Vitro Models for Parkinson Disease Research\u2014Old Practice for New Trends.<\/em> Journal of Integrative Neuroscience. 2023;22(1):20.<\/strong><\/span><\/li>
      2. Manole E., Ceafalan L.C., Gaina G.F., Mosoia O.A., Hinescu M.E. Myokine expression in cancer cachexia.<\/em> \u00cen: Cancer Research: An Interdisciplinary Approach<\/em>. Springer, 2023.<\/strong><\/span><\/li>
      3. Lambrescu I., Manole E., Ceafalan L.C., Gaina G. The potential benefits of drug-repositioning in muscular dystrophies.<\/em> \u00cen: Potential Therapeutic Strategies for Muscular Dystrophy<\/em>. IntechOpen, 2023.<\/strong><\/span><\/li><\/ol>

        Communications<\/strong><\/span><\/p>

        1. Bastian A., Manole E. Pathological aspects and classification criteria of inflammatory myopathies.<\/em> International Pathology Conference of the \u201cVictor Babe\u0219\u201d Institute, Bucharest, Romania, 2\u20134 November 2023. Book of Abstracts, p. 53. Oral presentation.<\/strong><\/span><\/li>
        2. Manole E., Gaina G., Lambrescu I., Ceafalan L. The involvement of Parkin in the skeletal muscle phenotype in Parkinson\u2019s disease.<\/em> International Pathology Conference of the \u201cVictor Babe\u0219\u201d Institute, Bucharest, Romania, 2\u20134 November 2023. Book of Abstracts, p. 55. Oral presentation.<\/strong><\/span><\/li><\/ol>

          2024<\/strong><\/span><\/p>

          Articole \u0219tiin\u021bifice<\/strong><\/span><\/p>

          1. Ioghen O.C., Gaina G., Lambrescu I., Manole E., Pop S., Niculescu T.M., Mosoia O., Ceafalan L.C., Popescu B.O. Bacterial products initiation of alpha-synuclein pathology: an in vitro study.<\/em> Scientific Reports, 2024.
            DOI: 10.1038\/s41598-024-81020-x.<\/strong><\/span><\/li><\/ol>

            2026<\/strong><\/span><\/p>

            Articole \u0219tiin\u021bifice<\/strong><\/span><\/p>

            1. Popescu M.R., Panaitescu A.M., Ceafalan L.C., Hinescu M.E. CD36 as a Context-Dependent Regulator of Metabolic Switching in Acute and Chronic Hypoxia.<\/em> Biomolecules, 2026.
              DOI: 10.3390\/biom16071018.<\/strong><\/span><\/li>
            2. Pavalean M.I., Madan V.L., Pavalean M.C., Ceafalan L.C., Hinescu M.E. The role of CD36 in renal and bladder cancer.<\/em> Discoveries (Craiova), 2026.
              DOI: 10.15190\/d.2026.4.<\/strong><\/span><\/li>
            3. \u021a\u0103poi D.A., Lambrescu I.M., Manole C.G., Gaina G., Ceafalan L. Uncovering the Intricate and Heterogeneous Cellular Microenvironment of Cutaneous Melanoma.<\/em> Medicina, 2026.
              DOI: 10.3390\/medicina62040739.<\/strong><\/span><\/li>
            4. P\u0103v\u0103lean M.C., Lambrescu I.M., P\u0103v\u0103lean M.I., Gaina G., Ceafalan L., Hinescu M. Screening, Prognostic, and Predictive Molecular Tools for Colorectal Cancer: Recent Advances in the Classical Background.<\/em> International Journal of Molecular Sciences, 2026.
              DOI: 10.3390\/ijms27052251.<\/strong><\/span><\/li>
            5. Pavalean M.I., Lambrescu I.M., Gaina G., Madan V.L., Hinescu M.E., Ceafalan L.C. CD36 rs1761667 Polymorphism and Its Impact on Molecular Signatures in Bladder Cancer.<\/em> Diseases, 2026.
              DOI: 10.3390\/diseases14020044.<\/strong><\/span><\/li><\/ol>

              Abstract de conferin\u021b\u0103 publicat<\/strong><\/span><\/p>

              1. Pop S., Cismasiu V.B., Dudau M., Marinescu R.M., Stroe A.M., Alexandru G., Tomescu J.A., Neagu M. Bioactive effects of cold-pressed seed oil extracts: in vitro analysis using hepatic cell models.<\/em> BMC Proceedings, 2026;20(Suppl 5).
                DOI: 10.1186\/s12919-025-00359-9.<\/strong><\/span><\/li><\/ol>

                Men\u021bionarea finan\u021b\u0103rii<\/strong><\/span><\/p>

                Publica\u021biile incluse \u00een aceast\u0103 sec\u021biune recunosc finan\u021barea acordat\u0103 prin Programul Nucleu \u2013 proiect PN 23.16.01.02, conform men\u021biunilor de finan\u021bare\/acknowledgements din lucr\u0103rile respective.<\/strong><\/span><\/p>

                \u00a0<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

                PN 23.16.01.02 Sarcopenia asociat\u0103 bolilor neurodegenerative: definirea bazei moleculare de inter-rela\u021bionare pe axa creier-mu\u0219chi striat pentru identificarea unor factori de prognostic \u0219i \u021binte terapeutice Contract nr. 10N\/2023\u00a0\u00a0\u00a0 Finan\u021bator: Ministerul Cercet\u0103rii, Inov\u0103rii \u0219i Digitaliz\u0103rii Durata: 2023-2025 \u00cen cadrul Programului Nucleu: Mecanisme moleculare \u00een bolile netransmisibile majore \u2013 de la cancer la patologia degenerativ\u0103, de la dimensiunea… <\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6179","page","type-page","status-publish","hentry"],"yoast_head":"\nPN 23.16.01.02 - National Institute of Pathology Victor Babe\u015f - Bucharest<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ivb.ro\/en\/pn-23-16-01-02\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PN 23.16.01.02 - 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