Before Alzheimer’s Disease: novel mechanism of amyloid precursor protein signaling in adult healthy brain
Institution: Victor Babes National Institute of Research Development in the Pathology Domain and Biomedical Sciences
PI: Dr. Ana-Maria Enciu, MD, PhD
Funding: State Bugdet through Romanian National Authority for Scientific Research and Innovation CNCS-UEFISCDI
Contract no: PN-II-RU-TE-2014-4-1534
Main objective: Demonstration of APP oligomerization in healthy adult mouse brain, conditionned by membrane microdomains. We propose here a new mechanism of APP signaling and bring the first arguments and the technical means for a more complex demonstration.