Publications Radiobiology

Publications & Patents

  1. Livia Elena Chilug, Dana Niculae, Radu Anton Leonte, Alexandrina Nan, Rodica Turcu, Cosmin Mustaciosu, Radu Marian Serban, Vasile Lavric, Gina Manda. Preclinical Evaluation of NHS-Activated Gold Nanoparticles Functionalized with Bombesin or Neurotensin-Like Peptides for Targeting Colon and Prostate Tumours. Molecules 2020, 25: 3363.
  2. Antonio Cuadrado, Marta Pajares, Cristina Benito, José Jiménez-Villegas, Maribel Escoll, Raquel Fernández-Ginés, Angel J. Garcia Yagüe, Diego Lastra, Gina Manda, Ana I. Rojo, Albena T. Dinkova-Kostova. Can Activation of NRF2 Be a Strategy against COVID-19? Trends in Pharmacological Sciences, 1738, 22 July 2020.
  3. Marta Pajares, Ana I. Rojo, Gina Manda, Lisardo Boscá, Antonio Cuadrado. Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications. Cells 2020, 9(7), 1687.
  4. Norwin Kubick, Marta Pajares, Ioana Enache, Gina Manda, Michel-Edwar Mickael. Repurposing Zileuton as a Depression Drug Using an AI and In Vitro Approach. Molecules 2020, 25(9): 2155.
  5. Funieru C, Obagiu IA, Oancea R, Dobrica B, Sfeatcu RI, Nicolescu MI. Erosive Potential of Three Different Beverages on Human Enamel and Dentine: An in vitro Study. Revista de Chimie, 71(3):192-196, 2020.
  6. Nicolescu MI, Rusu MC, Voinea LM, Vrapciu AD, Bâră R. Lymphatic lacunae of the human eye conjunctiva embedded within a stroma containing CD34+ telocytes. Journal of Cellular and Molecular Medicine, 24(15):8871-8875, 2020.
  1. Gina Manda, Cristian Postolache, Ionela Victoria Neagoe, Andreea Csolti, Elena Milanesi, Maria Dobre. The expression profile of redox genes in human monocytes exposed in vitro to γ radiation. Radiation Physics and Chemistry 2019, 170: 108634.
  2. Gina Manda, Ana I. Rojo, Elena Martínez-Klimova , José Pedraza-Chaverri, Antonio Cuadrado. Nordihydroguaiaretic acid: from herbal medicine to clinical development for cancer and chronic diseases. Frontiers Pharmacology 2019, 11:151.
  3. Alina-Andreea Zimta, Vlad Schitcu, Eugen Gurzau, Crina Stavaru, Gina Manda, Stefan Szedlacsek, Ioana Berindan-Neagoe. Biological and molecular modifications induced by cadmium and arsenic during breast and prostate cancer development. Environmental Research 2019, 178: 108700, https://doi.org/10.1016/j.envres.2019.108700.
  4. Asavei T, Bobeica M, Nastasa V, Manda G, et al. Laser-driven radiation: Biomarkers for molecular imaging of high dose-rate effects. Medical Physics 2019, 46(10): e726-e734.
  5. Robledinos-Anton N, Fernandez-Gines R, Manda G, Cuadrado A. Activators and inhibitors of NRF2: A review of their potential for clinical development. Oxid Med Cell Longev 2019, 2019:9372182.
  6. Radu Albulescu, Adrian-Claudiu Popa, Ana-Maria Enciu, Lucian Albulescu, Maria Dudau, Ionela Daniela Popescu, Simona Mihai, Elena Codrici, Sevinci Pop, Andreea-Roxana Lupu, George E Stan, Gina Manda, Cristiana Tanase. Comprehensive In Vitro Testing of Calcium Phosphate-Based Bioceramics with Orthopedic and Dentistry Applications. Materials 2019, 12(22): 3704.
  7. Natalia Radulea, Rica Boscencu, Radu Socoteanu, Gina Manda, Ionela Victoria Neagoe. The Effect of Some Amphiphilic Porphyrins on the Transmembrane Potential of Cultured L929 Cells. Revista de Chimie 2019, 70(4): 1288-1292.
  8. Gina Manda, Mihail Eugen Hinescu, Ionela Victoria Neagoe, Luis Filipe Vieira Ferreira, Rica Boscencu, Paul Vasos, Selma Huveyda Basaga, Antonio Cuadrado. Emerging Therapeutic Targets in Oncologic Photodynamic Therapy. Current Pharmaceutical Design 2019, 24(44): 5268-5295.
  9. Ionescu A, Dodi A, Panagopoulos V, Nicolescu MI, Mihai AT, Tanase G, Vlasceanu D. Biomechanical consequences of dental implants inserted in augmented alveolar ridges – a comparative study between tissue-level and bone-level implants: finite elements analysis. Romanian Journal of Oral Rehabilitation, 11(1):82-88, 2019.
  10. Rusu MC, Nicolescu MI, Jianu AM, Manoiu VS, Ilie C, Dinca D. The ultrastructural anatomy of the nuclear envelope in the masseter muscle indicates its role in the metabolism of the intracellular Ca++. Annals of Anatomy-Anatomischer Anzeiger, 224:117-123, 2019.
  11. Manole CG, Marinescu BG, Marta D, Nicolescu MI. Areas of cartilaginous and osseous metaplasia after experimental myocardial infarction in rats. The Anatomical Record, 302(6):947-953, 2019.
  12. Istrate-Ofiţeru AM, Pîrvan IC, Pirici D, Roşu GC, Niculescu M, Berceanu S, Manolea MM, Comănescu MV, Voicu NL, Iovan L, Vasile MM, Căpitănescu RG, Diţescu D, Mogoantă L, Berceanu C. Triple immunohistochemistry for assessing the inflammatory, vascular and progression of adenomyosis. Rom J Morphol Embryol, 60(2):419-428, 2019.
  1. Panait ME, Chilug L, Negoita V, Busca A, Manda G, Niculae D, Dumitru M, Gruia MI. Biological effects induced by 68Ga – conjugated peptides in human and rodent tumor cell lines. Molecular Imaging and Biology 2018, 25: 979–987.
  2. Boscencu R, Socoteanu RP, Manda G et al. New A3B porphyrins as potential candidates for theranostic. Synthesis and photochemical behaviour. Dyes and Pigments 2018, 160: 410-417.
  3. Codeanu C, Popescu CC, Mogosan C, Enache L, Manda G, Berghea F, Groseanu L, Predeteanu D. Targeting interleukin 17 in the treatment of rheumatoid arthritis. Farmacia 2018, 66(3): 390-398.
  4. Antonio Cuadrado, Gina Manda, Ahmed Hassan, et al. Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach. Pharmacological Reviews 2018, 70(2):348-383.
  5. Pietro Ghezzi, Luciano Floridi, Diana Boraschi, Antonio Cuadrado, Gina Manda, Snezana Levic, Fulvio D’Acquisto, Alice Hamilton, Toby J Athersuch, Liza Selley. Oxidative stress and inflammation induced by environmental and psychological stressors: A biomarker perspective, Antioxidants & redox signaling 2018, 28(9): 852-872.
  6. Cionca FL, Dobre M, Dobrea CM, Iosif CI, Comănescu MV, ArdeleanuMutational status of KRAS and MMR genes in a series of colorectal carcinoma cases. Rom J Morphol Embryol, 59(1):121-129, 2018.
  7. Corici OA, Tanasie CA, Alexandru DO, Florescu MC, Comănescu MV, Kamal KC, Ţenea-Cojan TŞ, Iancău M, Dinescu A morpho-functional study using PEP/LVET ratio and global longitudinal strain in patients with dilated cardiomyopathy. Rom J Morphol Embryol, 59(1):93-103, 2018.
  1. Burns JS, Manda G. Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance, International Journal of Molecular Science 2017, 18(12):2755.
  2. Rica Boscencu, Gina Manda, Natalia Radulea, Radu Petre Socoteanu, Laura Cristina Ceafalan, Ionela Victoria Neagoe, Isabel Ferreira Machado, Selma Huveyda Basaga, Luís Filipe Vieira Ferreira. Studies on the Synthesis, Photophysical and Biological Evaluation of Some Unsymmetrical Meso-Tetrasubstituted Phenyl Porphyrins, Molecules 2017, 22(11): 1815.
  3. Chilug LE, Leonte RA, Barbinte Patrascu ME, Ion AC, Tuta CS, Raicu A, Manda G, Niculae D. In vitro binding kinetics study of gold nanoparticles functionalized with 68Ga-DOTA conjugated peptides. J Radioanal Nucl Chem 2017, 3(2):1485-1493.
  4. Barca M, Manda G, Ciobanu AM, Balalau C, Lupuleasa D, Traian G, Dragomiroiu GTAB, Pop A, Popa DE, Baconi DL. Immunomodulatory effects of methadone following methotrexate therapy in a rat model of arthritis, Farmacia 2017, 65(3):423-428.
  1. Asavei T, Tomut M, Bobeica M, Aogaki S, Cernaianu MO, Ganciu M, Kara S, Manda G, et al. Materials in extreme environments for energy, accelerators and space applications at ELI-NP, Romanian Reports in Physics 2016, 68(Suppl): S275–S347.
  2. Checheriţă IA, Manda G, Hinescu ME, Peride I, Niculae A, Bilha S, Gramaticu A, Voroneanu L, Covic A. New molecular insights in diabetic nephropathy. International Urology and Nephrology 2016, 48(3): 373-387.
  3. Nicolescu MI. Telocytes in Exocrine Glands Stroma. Advances in Experimental Medicine and Biologies, 913:163-176, 2016.
  4. Calenic B, Greabu M, Caruntu C, Nicolescu MI, Moraru, Surdu-Bob CC, Badulescu M, Anghel A, Logofatu C, Boda D.Oral keratinocyte stem cells behavior on diamond like carbon films. Romanian Biotechnological Letters, 21(5):11914-11922, 2016.
  1. Dumitrache F, Morjan IG, Fleaca CI, Badoi A, Manda G, Pop S, Marta DS, et.al. Highly magnetic Fe2O3 nanoparticles synthesized by laser pyrolysis used for biological and heat transfer applications. Applied Surface Science 2015, 336: 297–303.
  2. Socoteanu R, Manda G, Boscencu R, Vasiliu G, Anabela Sousa Oliveira. Synthesis, spectral analysis and preliminary in vitro evaluation of some tetrapyrrolic complexes with 3d metal ions. Molecules 2015, 20(9): 15488-15499, doi:10.3390/molecules200915488.
  3. Manda G, Isvoranu G, Comanescu MV, Manea A, Debelec Butuner B, Korkmaz KS. The redox biology network in cancer pathophysiology and therapeutics. Redox Biology 2015, 5: 347-357.
  4. Manea SA, Constantin A, Manda G, Sasson S, Manea A. Regulation of Nox enzymes expression in vascular pathophysiology: Focusing on transcription factors and epigenetic mechanisms. Redox Biology 2015, 5: 358-366.
  5. Manda G, Mocanu MA, Marin DE, Taranu I. Dual Effects Exerted in Vitro by Micromolar Concentrations of Deoxynivalenol on Undifferentiated Caco-2 Cells. Toxins 2015, 7(2), 593-603.
  6. Manda G, Checherita AI, Comanescu MV, Hinescu ME. Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes. Mediators of Inflammation 2015, 2015, Article ID 604208.
  7. Rusu MC, Poalelungi CV, Vrapciu AD, Nicolescu MI*, Hostiuc S, Mogoanta L, Taranu T. Endocardial Tip Cells in the Human Embryo – Facts and Hypotheses. PLoS One, 10(1): e0115853, 2015.
  8. Rusu MC, Hostiuc S, Dermengiu D, Nicolescu MI, Jianu AM. STRO-1 positive pulmonary valve stem cells: preliminary report. Romanian Journal of Legal Medicine. 23(1):1-4, 2015.
  1. Margina D, Ilie M, Manda G, Neagoe I, Danciulescu-Miulescu R, Purdel CD, Gradinaru D. In vitro effects of prolonged exposure to quercetin and epigallocatechin gallate of the peripheral blood mononuclear cell membrane. Cellular and Molecular Biology Letters 2014, 19: 542-560.
  1. Margina D, Gradinaru D, Manda G, Neagoe I, Ilie M. Membranar effects exerted in vitro by polyphenols – quercetin, epigallocatechin gallate and curcumin – on HUVEC and Jurkat cells, relevant for diabetes mellitus. Food Chem Toxicol, 61:86-93, 2013, pii: S0278-6915(13)00155-5.

Nechifor MT, Niculiţe CM, Urs AO, Regalia T, Mocanu M, Popescu A, Manda G, Dinu D, Leabu M. UVA Irradiation of Dysplastic Keratinocytes: Oxidative Damage versus Antioxidant Defense. Int. J. Mol. Sci, 13, 16718-16736, 2012

  1. Rusu MC, Mirancea N, Manoiu VS, Valcu M, Nicolescu MI, Paduraru D. Skin telocytes. Annals of Anatomy, 194(4):359-367, 2012.
  2. Nicolescu MI, A Bucur, O Dinca, MC Rusu, Popescu LM. Telocytes in Parotid Glands.The Anatomical Record, 295(3):378-385, 2012.
  3. Nicolescu MI, Popescu LM. Telocytes in the interstitium of human exocrine pancreas: ultrastructural evidence. Pancreas, 41(6):949-956, 2012.

Rusu MC, Nicolescu MI, Jianu AM, Lighezan R, Manoiu VS, Paduraru D. Esophageal telocytes and hybrid morphologies. Cell Biology International, 36(12):1079-1088, 2012

  1. Marin DE, Taranu I, Burlacu R, Manda G, Motiu M, Neagoe I, Dragomir C, Stancu M, Calin L. Effects of zearalenone and its derivatives on porcine immune response. Toxicology In Vitro. 25(8):1981-1988, 2011.
  2. Taranu I, Daniela E. Marin DE, Manda G, Motiu M, Ionela Neagoe I, Cristina Tabuc C, Stancu M, Olteanu M. Assessment of the potential of a boron–fructose additive in counteracting the toxic effect of Fusarium mycotoxins. Br J Nutrition, 106(3): 398-407, 2011.
  3. Enciu AM, Nicolescu MI, Manole CG, Muresanu DF, Popescu LM, Popescu BO. Neuroregeneration in neurodegenerative disorders. BMC Neurology, 11:75, 2011.
  1. Rica Boscencu, Mihaela Ilie, Radu Socoteanu, Anabela Sousa Oliveira, Carolina

Constantin, Monica Neagu, Gina Manda, Luis Filipe Vieira Ferreira. Synthesis, Basic Spectral and Biological Evaluation of Some Copper (II) Mesoporphyrinic Complexes. Molecules, 15(5), 3731-3743, 2010.

  1. Lidia Matei, Ionela Neagoe, C. Postolache, C.V. Tanase, G. Bubueanu, Gina Manda. In vitro and in vivo Radiometrical Studies For Evaluation of New Nucleoside Analogue Behavior. Label Compd. Radiopharm. 53: 294-299, 2010.
  2. Suciu L, Popescu LM, Gherghiceanu M, Regalia T, Nicolescu MI, Hinescu ME, Faussone-Pellegrini MS. Telocytes in human term placenta: morphology and phenotype. Cells Tissues Organs, 192(5): 325-339, 2010.
  3. Popescu LM, Manole CG, Gherghiceanu M, Ardelean A, Nicolescu MI, Hinescu ME, Kostin S. Telocytes in human epicardium. Journal of Cellular and Molecular Medicine, 14(8): 2085-2093, 2010.
  4. Suciu L, Nicolescu MI, Popescu LM. Cardiac telocytes: serial dynamic images in cell culture. Journal of Cellular and Molecular Medicine, 14(11): 2687-2692, 2010.
  1. Gina Manda, Marina Tamara Nechifor, Teodora-Monica Neagu. Reactive Oxygen Species, Cancer and Anti-Cancer Therapies. Current Chemical Biology, 3(1): 342-366, 2009.
  2. Gina Manda, Monica Neagu, Carolina Constantin, Ionela Neagoe, Catalin Codreanu. Preliminary study on the immunologic background of good clinical outcome in rheumatoid arthritis patients after one-month therapy with leflunomide. Rheumathology International, 29(8): 937-946, 2009.
  3. Tanase CP, Dima S, Mihai M, Raducan E, Nicolescu MI, Albulescu L, Voiculescu B, Dumitrascu T, Cruceru LM, Leabu M, Popescu I, Hinescu ME. Caveolin-1 overexpression correlates with tumour progression markers in pancreatic ductal adenocarcinoma. Journal of Molecular Histology, 40(1):23-29, 2009.
  • OSIM patent 131946/2019 Tetrapyrrolic compound with theranostic applications and obtaining process – authors: Boscencu R, Manda G, Socoteanu RP, Hinescu ME, Radulea N, Neagoe IV, Ferreira LFV.
  • OSIM patent 01030/2017 Porphyrin derivative for theranostic use – authors: Boscencu R, Manda G, Socoteanu RP, Hinescu ME, Neagoe I, Olariu L, Dumitriu B.
  • OSIM patent 125018 B1/2015 Biofunctionalized porphyrinic compound – authors: Socoteanu R, Boscencu R, Nacea V, Constantin C, Manda G, Neagu M, Ilie M, Oliveira AS, Ferreira LFV, published in RO-BOPI 4/30.04.2015
  • OSIM patent 126761 B1/2014 Asymmetrically substituted porphyrinic compound, as a photosensitizing agent, used in cancer diagnosis and its preparation process – authors: Boscencu R, Socoteanu R, Constantin C, Neagu M, Manda G, Ilie M, Nacea V, Gird CE, Oliveira AS, Ferreira LFV.
  • OSIM patent 128433 A2/2013 Procedure for the identification and dosing by HPLC of leflunomide in the patients’ blood – authors: Negrei C, Baconi D, Margină D, Bălănescu A, Berghea F, Ilie M, Manda G, published in RO-BOPI 5/30.05.2013
  • OSIM patent 123419 B1/2012 Asymmetrically substituted tetrapyrrolic compound, obtaining process and biological evaluation at cellular level – authors: Boscencu R, Socoteanu R, Nacea V, Constantin C, Manda G, Neagu M, Ilie M, Baconi DL, Oliveira AS, Ferreira LFV, published in RO-BOPI 3/30.03.2012